ITIH4 Antibody

Datasheet

Code	CSB-PA011897LA01HU
Size	US$166
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Image	IHC image of CSB-PA011897LA01HU diluted at 1:300 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. IHC image of CSB-PA011897LA01HU diluted at 1:300 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) ITIH4 Polyclonal antibody

Uniprot No.

Q14624

Target Names

ITIH4

Alternative Names

35 kDa inter-alpha-trypsin inhibitor heavy chain H4 antibody; gp120 antibody; H4P antibody; IHRP antibody; Inter-alpha-inhibitor heavy chain 4 antibody; Inter-alpha-trypsin inhibitor family heavy chain-related protein antibody; Inter-alpha-trypsin inhibitor heavy chain H4 antibody; inter-alpha-trypsin inhibitor, heavy chain-like, 1 antibody; ITI heavy chain H4 antibody; ITI-HC4 antibody; ITIH4 antibody; ITIH4_HUMAN antibody; ITIHL1 antibody; OTTHUMP00000197120 antibody; OTTHUMP00000197121 antibody; OTTHUMP00000213834 antibody; OTTHUMP00000213869 antibody; PK-120 antibody; PK120 antibody; Plasma kallikrein sensitive glycoprotein 120 antibody; PRO1851 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Inter-alpha-trypsin inhibitor heavy chain H4 protein (689-930AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The ITIH4 Antibody (Product code: CSB-PA011897LA01HU) is Non-conjugated. For ITIH4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA011897LB01HU	ITIH4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA011897LC01HU	ITIH4 Antibody, FITC conjugated
Biotin	CSB-PA011897LD01HU	ITIH4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Type II acute-phase protein (APP) involved in inflammatory responses to trauma. May also play a role in liver development or regeneration.

Gene References into Functions

Low ITIH4 expression is associated with Hepatocellular Carcinoma. PMID: 28828637
this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex PMID: 26991396
ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications PMID: 26408095
Serum ITIH4 may be a PM10-specific biomarker in COPD and may be related to inflammation. PMID: 25977605
Four novel body mass index-associated loci near the KCNQ1(rs2237892), ALDH2/MYL2 (rs671, rs12229654), ITIH4 (rs2535633) and NT5C2 (rs11191580) genes are identified in East Asian-ancestry populations. PMID: 24861553
Worse survival among HCC patients with low ITIH4. PMID: 24836184
Isoform-specific ITIH4 glycosylation and utilization of O-glycosylation sites on ITIH4 differs between cell lines and serum. PMID: 24884609
Expression of the 85 kDa ITIH4 was substantial in amyotrophic lateral sclerosis compared with controls or patients with muscular dystrophy, Alzheimer diseases, or Parkinson diseases PMID: 23436019
A truncated fragment of inter-alpha-trypsin inhibitor heavy chain 4 was the sole protein found to be significantly enhanced in the prostate cancer patients compared to the controls. PMID: 23417432
Findings suggest that ITI-H4 expression may be used as a biomarker, which could facilitate the development of novel diagnostic and therapeutic tools. PMID: 21331437
Genetic variation at ITIH4 locus is one of the likely candidate determinants for plasma cholesterol metabolisms PMID: 14661079
ITIH4 and MTJ1 co-immunoprecipitate from total liver protein extracts and SANT domain of HTJ1 protects the ITIH4(588-930) recombinant fragment PMID: 16271702
The inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) protein was significantly present more in interstial cystitis than controls PMID: 18455532
ITIH4 is an anti-inflammatory protein, and suggests that further investigation into its potential use in the diagnosis and prognosis of acute ischemic stroke is warranted. PMID: 19263524

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Subcellular Location

Secreted.

Protein Families

ITIH family

Tissue Specificity

Liver specific.

Database Links

HGNC: 6169

OMIM: 600564

KEGG: hsa:3700

STRING: 9606.ENSP00000266041

UniGene: Hs.709406

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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