ITPKC Antibody

Code CSB-PA876631
Size US$297
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  • Western blot analysis of extracts from HT-29 cells, using IP3KC antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ITPKC Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
4 antibody; 5-trisphosphate 3-kinase C antibody; Inositol 1 antibody; inositol 1,4,5 trisphosphate 3 kinase C antibody; Inositol trisphosphate 3 kinase C antibody; Inositol-trisphosphate 3-kinase C antibody; InsP 3 kinase C antibody; InsP 3-kinase C antibody; IP3 3-kinase C antibody; IP3 3KC antibody; IP3K C antibody; IP3KC antibody; IP3KC_HUMAN antibody; Itpkc antibody
Raised in
Species Reactivity
Synthesized peptide derived from internal of Human IP3KC.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.
Gene References into Functions
  1. This study identified several important polymorphisms in the ITPKC and SLC11A1 genes in Koreans. PMID: 29214786
  2. Genetic variants of ITPKC may have a potential association with HSCR (Hirschsprung disease) susceptibility and/or developmental diseases related to enteric nervous system development. PMID: 28664405
  3. this study shows that the KD-associated genetic polymorphism in inositol-triphosphate 3-kinase C (ITPKC) (rs28493229) has important functional consequences, governing ITPKC protein levels and thereby intracellular calcium, which in turn regulates NLRP3 expression and production of IL-1beta and IL-18. PMID: 27694492
  4. ITPKC polymorphisms are associated with Kawasaki disease. PMID: 24903211
  5. SNP rs7251246 in ITPKC is associated with the severity of Kawasaki disease PMID: 24621571
  6. Our results identify a novel polymorphism for renal function and highlight the importance of ITPKC as a key molecule to regulate calcium signaling. PMID: 24800221
  7. a combinatorial association between ITPKC (rs28493229) and CASP3 (rs113420705) was found in coronary artery lesion formation (P = 0.0227, OR: 3.06)in Taiwanese population PMID: 23894522
  8. functional studies demonstrated that PPP3CC positively influences the protein level of ITPKC, likely by inhibiting phosphorylation of ITPKC and consequently preventing ITPKC from ubiquitin-mediated protein degradation PMID: 23747857
  9. Functional single-nucleotide polymorphisms in ITPKC and CASP3 are associated with susceptibility to Kawasaki's disease (KD). PMID: 21987091
  10. the functional polymorphism rs28493229 in ITPKC significantly contributes to the risk of Kawasaki disease. PMID: 23065250
  11. The C allele of the ITPKC gene rs2290692 is linked to a significantly higher risk for KD in the Han Chinese population studied. PMID: 22361738
  12. ITPKC susceptibility in Kawasaki syndrome is related to its synergy with environmental triggers, such as thimerosal, which alter calcium homeostasis and promote oxidative stress. PMID: 22498790
  13. It was found the G/G genotype and G allele of the inositol 1,4,5-trisphosphate 3-kinase rs28493229 polymorphism may contribute to the risk of cervical squamous cell carcinoma in Taiwanese women. PMID: 22610085
  14. The study failed to prove any association between SNP rs28493229 of ITPKC gene and Kawasaki disease/coronary artery lesions in Chinese patients. PMID: 22161096
  15. results indicated that C-allele of ITPKC SNP rs28493229 is associated with the susceptibility and aneurysm formation in KD patients in a Taiwanese population PMID: 21533171
  16. Single nucleotide polymorphism rs28493229 in ITPKC contributes to Kawasaki disease susceptibility through induced hyperimmune function reflected in the BCG reactivation. PMID: 20805785
  17. A statistically significant association was not found between the ITPKC gene single-nucleotide polymorphism rs28493229 and Kawasaki disease or coronary artery lesions in Taiwanese children. PMID: 20045869
  18. results highlight the potential role of the three isoforms of InsP3 3-kinase as direct InsP3 metabolizing enzymes and direct regulators of Ca2+ responses to extracellular signals PMID: 12747803
  19. ITPKC acts as a negative regulator of T-cell activation through the Ca2+/NFAT signaling pathway, and the C allele may contribute to immune hyper-reactivity in Kawasaki disease. PMID: 18084290

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Involvement in disease
Kawasaki disease (KWD)
Subcellular Location
Nucleus. Cytoplasm. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.
Protein Families
Inositol phosphokinase (IPK) family
Tissue Specificity
Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.
Database Links

HGNC: 14897

OMIM: 606476

KEGG: hsa:80271

STRING: 9606.ENSP00000263370

UniGene: Hs.515415

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