KCNMB2 Antibody

Datasheet

Code	CSB-PA252563
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA252563(KCNMB2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA252563(KCNMB2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q9Y691

Target Names

KCNMB2

Alternative Names

2700049B16Rik antibody; 3110031N04Rik antibody; BK channel subunit beta 2 antibody; BK channel subunit beta-2 antibody; BKbeta2 antibody; Calcium activated potassium channel subfamily M subunit beta 2 antibody; Calcium activated potassium channel subunit beta 2 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-2 antibody; Charybdotoxin receptor subunit beta 2 antibody; Charybdotoxin receptor subunit beta-2 antibody; Hbeta2 antibody; Hbeta3 antibody; K(VCA)beta-2 antibody; K(VCA)beta2 antibody; KCMB2_HUMAN antibody; KCNMB 2 antibody; Kcnmb2 antibody; Large conductance Ca2+ activated K+ channel beta2 subunit antibody; Large conductance calcium activated potassium channel beta 2 subunit antibody; Maxi K channel subunit beta 2 antibody; Maxi K channel subunit beta-2 antibody; MaxiK channel beta 2 subunit antibody; MGC22431 antibody; MGC57945 antibody; Potassium large conductance calcium activated channel subfamily M beta member 2 antibody; Slo-beta-2 antibody; Slobeta2 antibody; subfamily M subunit beta-2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human KCNMB2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:10000
IHC	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.

Gene References into Functions

IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased). PMID: 24414257
beta subunits of large-conductance calcium-dependent potassium channels modulate the interface between membrane-spanning and cytosolic domains. PMID: 23825428
results reveal the molecular regions in the beta1 and beta2 subunits that determine their differential functional coupling with the pore-forming alpha-subunit PMID: 16446507
significance of inactivation in BK channels mediated by beta subunits arises not from inactivation, but from differences in the amplitude and duration of repolarizing currents arising from the beta-subunit-specific energetics of recovery from inactivation PMID: 17460083
reports that coexpression of beta2 subunit (KCNMB2) with hSlo can also modulate hSlo surface expression levels in HEK293T cells PMID: 17521822
Report beta subunit (KNMB1-4)-specific modulations of BK channel function by a Slo1 mutation associated with epilepsy and dyskinesia. PMID: 19204046

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Subcellular Location

Membrane; Multi-pass membrane protein.

Protein Families

KCNMB (TC 8.A.14.1) family, KCNMB2 subfamily

Tissue Specificity

Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.

Database Links

HGNC: 6286

OMIM: 605214

KEGG: hsa:10242

STRING: 9606.ENSP00000351068

UniGene: Hs.478368

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Vascular smooth muscle contraction cGMP-PKG signaling pathway

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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