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KCNMB2 Antibody

Datasheet
Code CSB-PA130865
Size US$297
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Image
  • Western blot analysis of extracts from HepG2 cells, COLO cells and Jurkat cells, using KCNMB2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) KCNMB2 Polyclonal antibody
Uniprot No.
Q9Y691
Target Names
KCNMB2
Alternative Names
2700049B16Rik antibody; 3110031N04Rik antibody; BK channel subunit beta 2 antibody; BK channel subunit beta-2 antibody; BKbeta2 antibody; Calcium activated potassium channel subfamily M subunit beta 2 antibody; Calcium activated potassium channel subunit beta 2 antibody; Calcium-activated potassium channel antibody; Calcium-activated potassium channel subunit beta-2 antibody; Charybdotoxin receptor subunit beta 2 antibody; Charybdotoxin receptor subunit beta-2 antibody; Hbeta2 antibody; Hbeta3 antibody; K(VCA)beta-2 antibody; K(VCA)beta2 antibody; KCMB2_HUMAN antibody; KCNMB 2 antibody; Kcnmb2 antibody; Large conductance Ca2+ activated K+ channel beta2 subunit antibody; Large conductance calcium activated potassium channel beta 2 subunit antibody; Maxi K channel subunit beta 2 antibody; Maxi K channel subunit beta-2 antibody; MaxiK channel beta 2 subunit antibody; MGC22431 antibody; MGC57945 antibody; Potassium large conductance calcium activated channel subfamily M beta member 2 antibody; Slo-beta-2 antibody; Slobeta2 antibody; subfamily M subunit beta-2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human KCNMB2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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KCNMB2 Antibodies

KCNMB2 Proteins

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Target Background

Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons.
Gene References into Functions
  1. IFN-gamma changed mRNA levels of the BK beta-modulatory proteins KCNMB2 (increased) and KCNMB4 (decreased) as well as leucine-rich repeat-containing protein (LRRC)26 (decreased). PMID: 24414257
  2. beta subunits of large-conductance calcium-dependent potassium channels modulate the interface between membrane-spanning and cytosolic domains. PMID: 23825428
  3. results reveal the molecular regions in the beta1 and beta2 subunits that determine their differential functional coupling with the pore-forming alpha-subunit PMID: 16446507
  4. significance of inactivation in BK channels mediated by beta subunits arises not from inactivation, but from differences in the amplitude and duration of repolarizing currents arising from the beta-subunit-specific energetics of recovery from inactivation PMID: 17460083
  5. reports that coexpression of beta2 subunit (KCNMB2) with hSlo can also modulate hSlo surface expression levels in HEK293T cells PMID: 17521822
  6. Report beta subunit (KNMB1-4)-specific modulations of BK channel function by a Slo1 mutation associated with epilepsy and dyskinesia. PMID: 19204046

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Subcellular Location
Membrane; Multi-pass membrane protein.
Protein Families
KCNMB (TC 8.A.14.1) family, KCNMB2 subfamily
Tissue Specificity
Expressed in kidney, heart and brain. Highly expressed in ovary. Expressed at low level in other tissues.
Database Links

HGNC: 6286

OMIM: 605214

KEGG: hsa:10242

STRING: 9606.ENSP00000351068

UniGene: Hs.478368

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Related pathways
Vascular smooth muscle contraction cGMP-PKG signaling pathway
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