KCNMB4 Antibody

1. Two recurrent fusion genes associated with the 12q locus, LRP1-SNRNP25 and KCNMB4-CCND3, were by RT-PCR, Sanger sequencing and FISH, and were found to be osteosarcoma specific in a validation cohort of 240 other sarcomas. PMID: 25300797
2. Recombinant martentoxin selectively blocks KCNMA1/KCNMB4 channels. PMID: 24759175
3. BK channel beta4 subunit influences sensitivity and tolerance to alcohol by altering its response to kinases PMID: 25190810
4. Study shows that beta4 subunit of the MaxiK channel has no potential endocytic signal and 2 specific amino acids in the functional basic motif retention/retrieval trafficking signal at the C-terminus may play a role in controlling cellular excitability PMID: 24486049
5. our data suggest that the rs398702 variant in the KCNMB4 gene is unlikely to influence significantly the risk of developing mesial temporal lobe epilepsy or its severity PMID: 23623847
6. These results suggest that fast-gating, type I BK channels lacking beta4 can increase neuronal excitability in response to reduced phosphatase activity and activation of calcium channels. PMID: 21848922
7. Structural basis for toxin resistance of beta4-associated calcium-activated potassium (BK) channels PMID: 18559348
8. The beta4 subunit controls ethanol tolerance at the molecular, cellular, and behavioral levels, and could determine individual differences in alcohol abuse and alcoholism, as well as represent a therapeutic target for alcoholism. PMID: 18981408
9. results argue that, for native mouse Slo3 channels, the beta4 subunit must be considered as a potential interaction partner and, furthermore, that KCNMB subunits may have functions unrelated to regulation of the Slo1 alpha subunit PMID: 19578543

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HGNC: 6289

OMIM: 605223

KEGG: hsa:27345

STRING: 9606.ENSP00000258111

UniGene: Hs.525529