KDM3B Antibody

Datasheet

Code	CSB-PA052445
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA052445(KDM3B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200) Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, 293T cells, mouse skeletal muscle tissue, Primary antibody: CSB-PA052445(KDM3B Antibody) at dilution 1/1000, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details
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Target Background

Product Details

Uniprot No.

Q7LBC6

Target Names

KDM3B

Alternative Names

5qNCA antibody; C5orf7 antibody; JHDM2B antibody; JmjC domain containing histone demethylation protein 2B antibody; JmjC domain-containing histone demethylation protein 2B antibody; jmjd1b antibody; Jumonji domain containing 1B antibody; Jumonji domain containing protein 1B antibody; Jumonji domain-containing protein 1B antibody; KDM3B antibody; KDM3B_HUMAN antibody; KIAA1082 antibody; Lysine (K) specific demethylase 3B antibody; Lysine-specific demethylase 3B antibody; NET22 antibody; Nuclear protein 5qNCA antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Fusion protein of Human KDM3B

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:2000-1:10000
WB	1:1000-1:5000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.

Gene References into Functions

we found that KDM3B exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML. PMID: 28540746
H3K9 demethylase KDM3B represses transcription of the angiogenesis regulatory gene, ANGPT1. PMID: 25413303
High expression of KDM3B and KDM5A is associated with a better prognosis (no recurrence after mastectomy p=0.005 and response to docetaxel p=0.005)in breast cancer patients. PMID: 23266085
evidence that the H3K9-me1/2 demethylase KDM3B might play a role in leukemogenesis via activation of lmo2 through interdependent actions with the histone acetyltransferase complex containing CBP PMID: 22615488
A novel nuclear protein, 5qNCA is a candidate for the myeloid leukemia tumor suppressor gene on chromosome 5 band q31. PMID: 11687974

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Subcellular Location

Nucleus.

Protein Families

JHDM2 histone demethylase family

Tissue Specificity

Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.

Database Links

HGNC: 1337

OMIM: 609373

KEGG: hsa:51780

STRING: 9606.ENSP00000326563

UniGene: Hs.483486

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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