KLB Antibody, FITC conjugated

Datasheet
Code CSB-PA769815LC01HU
Size US$299
Uniprot No. Q86Z14
Immunogen Recombinant Human Beta-klotho protein (1-130AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein), KLB
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Cardiovascular
Target Names KLB
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
Subcellular Location Cell membrane, Single-pass type III membrane protein
Protein Families Glycosyl hydrolase 1 family, Klotho subfamily
Database Links

HGNC: 15527

OMIM: 611135

KEGG: hsa:152831

STRING: 9606.ENSP00000257408

UniGene: Hs.90756

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