KLRC2 Antibody

1. a 16kb deletion encompassing the NKG2C gene is associated with lower carotid intimal media thickness values and higher humoral and T-cell responses to cytomegalovirus in renal transplant recipients PMID: 28987961
2. the data of this study extend the characterization of adaptive NK cell subsets that differentiate in response to human Cytomegalovirus, supporting a relationship between their distribution and NKG2C copy number PMID: 26994220
3. The new method offers the potential to use SNP arrays from genome wide association studies to study the frequency of KLRC2 deletion in other populations and its association with other diseases PMID: 27312142
4. Assessment of NK cell repertoires in 60 NKG2C(-/-) donors revealed a broad range of NK cell populations displaying characteristic footprints of adaptive NK cells, including a terminally differentiated phenotype, functional reprogramming, and epigenetic remodeling of the interferon (IFN)-gamma promoter. PMID: 27117418
5. HLA-E regulates NKG2C+ natural killer cell function through presentation of a restricted peptide repertoire PMID: 26382247
6. genetic polymorphism is not associated with nasopharyngeal carcinoma in China PMID: 25636564
7. Data suggest the proinflammatory potential of NKG2C(bright) NK cells. PMID: 25667418
8. lack of expression of NKG2C may be associated with altered control of human cytomegalovirus infection in childhood PMID: 25150297
9. No difference in the prevalence of NKG2C deletion was observed. PMID: 24305414
10. NKG2C receptor deletion and a functional polymorphism in its ligand HLA-E may play a role in psoriasis susceptibility PMID: 24079744
11. NKG2C(hi)CD57+ NK cells respond specifically to acute infection with cytomegalovirus and not Epstein-Barr virus. PMID: 24740502
12. NKG2Cnull does not seem to constitute a risk factor for HPV-induced cervical lesions. PMID: 23911737
13. NKG2C zygosity influences CD94/NKG2C receptor function and the NK-cell compartment redistribution in response to human cytomegalovirus. PMID: 24030638
14. coexpression of killer cell Ig-like receptor (KIR) and NKG2C on expanded NK cell subsets could be related to a functional contribution of KIR in cytomegalovirus infection PMID: 23918974
15. NKG2Chi CD57hi natural killer cells are highly responsive to human cytomegalovirus-infected macrophages only in the presence of HCMV-specific antibodies, whereas they are functionally poor effectors of natural cytotoxicity. PMID: 23637420
16. The increased expression of NKG2C in HIV patients indicate that NKG2C is important in the defense against HIV infection and progression. PMID: 22074011
17. A significantly elevated proportion of ex vivo peripheral blood CD4 T cells, but not CD8 T cells or natural killer (NK) cells, from multiple sclerosis patients express NKG2C, which contributes to tissue injury. PMID: 23396942
18. HCMV-infected NKG2C(+/+) children displayed higher absolute numbers of NKG2A(+) and total NK cells than NKG2C(+/-) individuals. PMID: 22965785
19. expression by Vdelta2+ T cells is lower in pregnant women PMID: 19395088
20. CD94/NKG2C might be involved in triggering cytotoxic lymphocytes in patients with Toxic epidermal necrolysis and Stevens-Johnson syndrome PMID: 20132973
21. Common occurrence of NKG2-C gene deletion in the general population. PMID: 12618865
22. NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases PMID: 14688071
23. strict gene regulatory mechanisms for CD94 and NKG2 gene expression on CD4+ cells PMID: 15550116
24. CD94/NKG2C may constitute an alternative T cell activation pathway capable of driving the expansion and triggering the effector functions of a cytotoxic T cell subset. PMID: 15940674

Show More

Hide All

HGNC: 6375

OMIM: 602891

KEGG: hsa:3822

STRING: 9606.ENSP00000371327

UniGene: Hs.591157