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LCMT1 Antibody, HRP conjugated

Datasheet
Code CSB-PA012808LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LCMT1 Polyclonal antibody
Uniprot No.
Q9UIC8
Target Names
LCMT1
Alternative Names
Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1), LCMT1, LCMT
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leucine carboxyl methyltransferase 1 protein (157-357aa)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
ELISA Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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LCMT1 Antibodies

LCMT1 Proteins

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Target Background

Function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Gene References into Functions
  1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. PMID: 23943618
  2. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A PMID: 21292165
  3. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A. PMID: 21206058
  4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development PMID: 17724024
Protein Families
Methyltransferase superfamily, LCMT family
Database Links

HGNC: 17557

OMIM: 610286

KEGG: hsa:51451

STRING: 9606.ENSP00000382021

UniGene: Hs.337730

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