LCMT1 Antibody

Datasheet

Code	CSB-PA012808LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HepG2 whole cell lysate, NTERA-2 whole cell lysate All lanes: LCMT1 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 39, 42, 33 kDa Observed band size: 39 kDa Immunofluorescence staining of A549 cells with CSB-PA012808LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LCMT1 Polyclonal antibody

Uniprot No.

Q9UIC8

Target Names

LCMT1

Alternative Names

Leucine carboxyl methyltransferase 1 (EC 2.1.1.233) (Protein-leucine O-methyltransferase) ([Phosphatase 2A protein]-leucine-carboxy methyltransferase 1), LCMT1, LCMT

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine carboxyl methyltransferase 1 protein (157-357aa)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LCMT1 Antibody (Product code: CSB-PA012808LA01HU) is Non-conjugated. For LCMT1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA012808LB01HU	LCMT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA012808LC01HU	LCMT1 Antibody, FITC conjugated
Biotin	CSB-PA012808LD01HU	LCMT1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Gene References into Functions

alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. PMID: 23943618
determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A PMID: 21292165
X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A. PMID: 21206058
LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development PMID: 17724024

Protein Families

Methyltransferase superfamily, LCMT family

Database Links

HGNC: 17557

OMIM: 610286

KEGG: hsa:51451

STRING: 9606.ENSP00000382021

UniGene: Hs.337730

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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