LCMT1 Antibody

Code CSB-PA523947
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA523947(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA523947(LCMT1 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: CSB-PA523947(LCMT1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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Product Details

Uniprot No.
Target Names
LCMT1
Alternative Names
[Phosphatase 2A protein]-leucine-carboxy methyltransferase 1 antibody; CGI 68 antibody; LCMT antibody; LCMT1 antibody; LCMT1_HUMAN antibody; Leucine carboxyl methyltransferase 1 antibody; PPMT1 antibody; Protein leucine O methyltransferase antibody; protein phosphatase methyltransferase 1 antibody; Protein-leucine O-methyltransferase antibody
Raised in
Rabbit
Species Reactivity
Human,Rat
Immunogen
Fusion protein of Human LCMT1
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
WB 1:200-1:1000
IHC 1:25-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.
Gene References into Functions
  1. alterations in the membrane localization of PP2A and Tau following down-regulation of LCMT1 may lead to PP2A and Tau dysfunction in AD. PMID: 23943618
  2. determined crystal structures of human LCMT-1 in isolation and in complex with PP2A stabilized by a cofactor mimic. The structures show that the LCMT-1 active-site pocket recognizes the carboxyl terminus of PP2A PMID: 21292165
  3. X-ray crystal structure of human LCMT1 protein in complex with the cofactor S-adenosylmethionine (AdoMet) has been solved to a resolution of 2 A. PMID: 21206058
  4. LCMT-1 is important for normal progression through mitosis and cell survival and is essential for embryonic development PMID: 17724024
Protein Families
Methyltransferase superfamily, LCMT family
Database Links

HGNC: 17557

OMIM: 610286

KEGG: hsa:51451

STRING: 9606.ENSP00000382021

UniGene: Hs.337730

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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