LEMD2 Antibody

Code CSB-PA854097LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: A549 whole cell lysate
    All lanes: LEMD2 antibody at 6.95µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 57, 24 kDa
    Observed band size: 57 kDa

  • IHC image of CSB-PA854097LA01HU diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LEMD2 Polyclonal antibody
Uniprot No.
Target Names
LEMD2
Alternative Names
LEMD2; LEM domain-containing protein 2; hLEM2
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human LEM domain-containing protein 2 protein (17-204AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LEMD2 Antibody (Product code: CSB-PA854097LA01HU) is Non-conjugated. For LEMD2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA854097LB01HU LEMD2 Antibody, HRP conjugated ELISA
FITC CSB-PA854097LC01HU LEMD2 Antibody, FITC conjugated
Biotin CSB-PA854097LD01HU LEMD2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:200-1:500
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in nuclear structure organization. Required for maintaining the integrity of the nuclear envelope.; Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling.
Gene References into Functions
  1. We conclude that Lem2p/LEM2 is a conserved nuclear site-specific adaptor that recruits Cmp7p/CHMP7 and downstream ESCRT factors to the nuclear envelope. PMID: 28242692
  2. Observational study of gene-disease association. (HuGE Navigator) PMID: 19851445
Involvement in disease
Cataract 46, juvenile-onset (CTRCT46)
Subcellular Location
Nucleus inner membrane; Multi-pass membrane protein. Note=Lamina-associated protein residing in the inner nuclear membrane (INM). Localized exclusively to the nuclear envelope, giving rise to a typical rim-like staining of the nuclear periphery.
Tissue Specificity
Ubiquitously expressed.
Database Links

HGNC: 21244

OMIM: 212500

KEGG: hsa:221496

STRING: 9606.ENSP00000293760

UniGene: Hs.444845

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