LPHN3 Antibody

1. An ultraconserved brain-specific enhancer within LPHN3 is associated with ADHD susceptibility. PMID: 27692237
2. Associations between LPHN1 and LPHN3 polymorphisms and severity of bronchial hyper-responsiveness in asthmatics were conducted; however, no associations were found. PMID: 27325752
3. Results suggest that UNC5 and LPHN3 can simultaneously bind to FLRT3, forming a trimeric complex, and that FLRT3 may form transsynaptic complexes with both LPHN3 and UNC5. PMID: 26235030
4. LPHN3 confers ADHD susceptibility, and moderates methylphenidate treatment response in children and adolescents with ADHD. PMID: 25989180
5. Study examined the association between the LPHN3 rs6551665 A/G polymorphism and Attention deficit hyperactivity disorder (ADHD) in Korea; samples used in the study consisted of 150 ADHD children and 322 controls; ADHD children appeared to have a surplus of GG genotype, studies with larger sample sizes needed. PMID: 25871512
6. genetic association studies in Germany: Data suggest that, within a sample of patients with attention deficit disorder hyperactivity, SNPs in LPHN3 gene impacts behavioral and neurophysiological measures of cognitive response control. PMID: 23245769
7. Increased LPHN3 mRNA expression levels correlated with axillary-node metastasis in breast cancer. PMID: 23317273
8. The influence of LPHN3 genotype on attention deficit-hyperactivity disorder (ADHD) and addiction is mediated through alterations in transgenic monoamine signaling. PMID: 22575564
9. A two-locus genetic interaction between LPHN3 and 11q predicts ADHD severity and long-term outcome. PMID: 22832519
10. This study identifying loci for aADHD and led to the identification of LPHN3 as novel genes associated with ADHD across the lifespan. PMID: 22105624
11. highly significant interaction between four SNPs and maternal stress during pregnancy and development of attention-deficit/hyperactivity disorder PMID: 22486528
12. single-nucleotide polymorphisms harbored in the LPHN3 gene interact with SNPs spanning the 11q region that contains DRD2 and NCAM1 genes, to double the risk of developing ADHD. PMID: 21606926
13. This study demonistrated that LPHN3 and its ligand FLRT3 play an important role in glutamatergic synapse development. PMID: 22405201
14. LPHN3, a new gene in which variants have recently been shown to be associated with adhd. PMID: 21432600
15. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder PMID: 21040458
16. The mutational analysis of the entire coding region of LPHN3 in a cohort of 139 attention deficit hyperactivity disorder subjects and 52 controls, is reported. PMID: 21184580

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HGNC: 20974

OMIM: 616417

KEGG: hsa:23284

STRING: 9606.ENSP00000422533

UniGene: Hs.28391