MAGED1 Antibody

Datasheet
Code CSB-PA896916DSR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q9Y5V3
Image
  • Immunohistochemistry of paraffin-embedded human glioma using CSB-PA896916DSR2HU at dilution of 1:100

Immunogen Recombinant Human Melanoma-associated antigen D1 protein (579-778AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias Melanoma-associated antigen D1 (MAGE tumor antigen CCF) (MAGE-D1 antigen) (Neurotrophin receptor-interacting MAGE homolog), MAGED1, NRAGE
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Cell Biology
Target Names MAGED1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3
Subcellular Location Cytoplasm, Cell membrane, Peripheral membrane protein, Nucleus
Tissue Specificity Expressed in bone marrow stromal cells from both multiple myeloma patients and healthy donors. Seems to be ubiquitously expressed.
Database Links

HGNC: 6813

OMIM: 300224

KEGG: hsa:9500

STRING: 9606.ENSP00000364847

UniGene: Hs.5258

Pathway Neurotrophin signaling pathway

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