MCM6 Antibody

1. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. PMID: 27624874
2. MCM6 is a highly reproducible marker of poor prognosis in endometrial cancer PMID: 29243125
3. genetic association studies in population in Western Europe: Data confirm an SNP in MCM6 (rs4988235) is predictive of milk consumption; lack of association of genetically predicted milk consumption with prevention of osteoporosis, ischemic heart disease, or type 2 diabetes suggests few beneficial effects of milk consumption but is more consistent with milk promoting adiposity/overweight. PMID: 28225053
4. Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma PMID: 26013954
5. Report presence of homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase gene in lactose intolerant patients treated with lactose-restricted diet. PMID: 25651706
6. Results indicate that the interaction between hCdt1 and hMcm6 through their interacting domains is key for hCdt1 in facilitating the MCM hetero-hexamer to load onto chromatin for replication licensing. PMID: 21099365
7. The subtype and MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor. PMID: 17294730
8. the molecular mechanism of Mcm2-7 chromatin loading and prereplicative complex assembly. PMID: 20202939
9. The numbers of the three genotypic combinations reveal that the percentage of this population that is genetically lactose intolerant is 8.23% and that the allele frequencies found are consistent with the expected Mendelian distribution. PMID: 20173814
10. Data show that cells subjected to chronic hypoxia the replicative restart was inhibited along with numerous replication factors including MCM6 and RPA, and cells reoxygenated after acute hypoxia underwent rapid p53-dependent apoptosis. PMID: 20103649
11. It was found that the MCM6 label index (LI) was significantly higher in adamantine epithelioma than squamous papillary tumor, and in both primary tumor subtypes the LIs of tumors with recurrence were higher than those without recurrence. PMID: 17410335

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HGNC: 6949

OMIM: 223100

KEGG: hsa:4175

STRING: 9606.ENSP00000264156

UniGene: Hs.444118