MCM6 Antibody

Code CSB-PA091656
Size US$166
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Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA091656(MCM6 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA091656(MCM6 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-4: 293T cells, K562 cells, NIH/3T3 cells, hela cells, Primary antibody: CSB-PA091656(MCM6 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
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Product Details

Uniprot No.
Target Names
MCM6
Alternative Names
DNA replication licensing factor MCM6 antibody; MCG40308 antibody; Mcm6 antibody; MCM6 minichromosome maintenance deficient 6 (MIS5 homolog; S. pombe) antibody; MCM6 minichromosome maintenance deficient 6 antibody; MCM6_HUMAN antibody; Minichromosome maintenance complex component 6 antibody; Minichromosome maintenance deficient (mis5 S. pombe) 6 antibody; Minichromosome maintenance deficient 6 homolog antibody; Minichromosome maintenance protein 6 antibody; Mis5 antibody; MIS5 homolog antibody; p105MCM antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Fusion protein of Human MCM6
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
Antigen affinity purification
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
Liquid
Tested Applications
ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
Gene References into Functions
  1. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. PMID: 27624874
  2. MCM6 is a highly reproducible marker of poor prognosis in endometrial cancer PMID: 29243125
  3. genetic association studies in population in Western Europe: Data confirm an SNP in MCM6 (rs4988235) is predictive of milk consumption; lack of association of genetically predicted milk consumption with prevention of osteoporosis, ischemic heart disease, or type 2 diabetes suggests few beneficial effects of milk consumption but is more consistent with milk promoting adiposity/overweight. PMID: 28225053
  4. Methyl(R217)HuR and MCM6 are inversely correlated and are prognostic markers in non small cell lung carcinoma PMID: 26013954
  5. Report presence of homozygous--13910CC genetic variant in the MCM-6 gene upstream from the lactase gene in lactose intolerant patients treated with lactose-restricted diet. PMID: 25651706
  6. Results indicate that the interaction between hCdt1 and hMcm6 through their interacting domains is key for hCdt1 in facilitating the MCM hetero-hexamer to load onto chromatin for replication licensing. PMID: 21099365
  7. The subtype and MCM6 protein expression in craniopharyngiomas are related to the prognosis of tumor. PMID: 17294730
  8. the molecular mechanism of Mcm2-7 chromatin loading and prereplicative complex assembly. PMID: 20202939
  9. The numbers of the three genotypic combinations reveal that the percentage of this population that is genetically lactose intolerant is 8.23% and that the allele frequencies found are consistent with the expected Mendelian distribution. PMID: 20173814
  10. Data show that cells subjected to chronic hypoxia the replicative restart was inhibited along with numerous replication factors including MCM6 and RPA, and cells reoxygenated after acute hypoxia underwent rapid p53-dependent apoptosis. PMID: 20103649
  11. It was found that the MCM6 label index (LI) was significantly higher in adamantine epithelioma than squamous papillary tumor, and in both primary tumor subtypes the LIs of tumors with recurrence were higher than those without recurrence. PMID: 17410335

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Subcellular Location
Nucleus. Chromosome.
Protein Families
MCM family
Database Links

HGNC: 6949

OMIM: 223100

KEGG: hsa:4175

STRING: 9606.ENSP00000264156

UniGene: Hs.444118

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