ME2 Antibody, FITC conjugated

Code CSB-PA013633HC01HU
Size US$299
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) ME2 Polyclonal antibody
Uniprot No. P23368
Target Names ME2
Alternative Names Malate dehydrogenase antibody; Malic enzyme 2 antibody; Malic enzyme 2 mitochondrial antibody; Malic enzyme 2 NAD(+) dependent mitochondrial antibody; Malic enzyme mitochondrial antibody; Malic enzyme NAD(+) dependent mitochondrial antibody; MAOM_HUMAN antibody; ME 2 antibody; ME2 antibody; mitochondrial antibody; NAD dependent malic enzyme mitochondrial antibody; NAD ME antibody; NAD-dependent malic enzyme antibody; NAD-ME antibody; ODS1 antibody; Pyruvic malic carboxylase antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human NAD-dependent malic enzyme, mitochondrial protein (296-424AA)
Immunogen Species Homo sapiens (Human)
Conjugate FITC
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form Liquid
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Gene References into Functions
  1. ME2 was involved in glioblastoma multiforme growth, invasion, migration, Reactive oxygen species and ATP production. PMID: 27166188
  2. deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer PMID: 28099419
  3. Data indicate that malic enzyme 2 knockdown impacts phosphatidylinositol 3-kinases/proto-oncogene protein akt (PI3K/AKT) signaling. PMID: 24957098
  4. ME2 might be an important factor in melanoma progression and a novel biomarker of invasion. PMID: 25202825
  5. Three SNP alleles in BRD2, Cx-36, and ME2 and microdeletions in 15q13.3, 15q11.2, and 16p13.11 also contribute risk to juvenile myclonic epilepsy. PMID: 23756480
  6. Depletion of malic enzyme 2 induced erythroid differentiation in human erythroleukemia cells. PMID: 20824065
  7. An ME2-centered nine-SNP haplotype, when present homozygously, increases the risk for IGE (odds ratio 6.1; 95% confidence interval 2.9-12.7) compared with any other genotype PMID: 15532013
  8. Site directed mutagenesis was used to detrmine which amino acids in the active site of human mitochondrial NAD+-dependent malic enzyme are necessary for the inhibitory effects of ATP. PMID: 16171388
  9. These findings provide a molecular rationale for the role of hS14 in TR-dependent transcriptional activation of the expression of specific genes. PMID: 17418816
  10. Schizophrenic subjects are identified with mitochondrial genes involved in oxidative metabolism as showing consistently decreased expression, including ME2. PMID: 17638511
  11. Single nucleotide polymorphism in ME2 gene is associated with acute lymphoblastic leukemia. PMID: 19066393
  12. ME2 activity in Islets of Langerhans cells was measured by a spectrophotometric enzyme assay by utilizing the distinct kinetic properties. PMID: 19691144

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Subcellular Location Mitochondrion matrix.
Protein Families Malic enzymes family
Database Links

HGNC: 6984

OMIM: 154270

KEGG: hsa:4200

STRING: 9606.ENSP00000321070

UniGene: Hs.233119

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