ME2

ME2, NADP-dependent malate enzyme 2, is a mitochondrial protein that serves as a vital auxiliary enzyme in the tricarboxylic acid (TCA) cycle. It catalyzes the conversion of malate to pyruvate, facilitating the production of NAD(P)H, which is essential for maintaining cellular metabolic balance. Beyond its primary role in energy metabolism, ME2 is significant in immune modulation; it affects fumarate levels, which regulate CD8+ T cell functionality and enhance antitumor immunity. Additionally, abnormal expression of ME2 has been linked to various cancer metabolic pathways, making it a key focus in cancer metabolism research. ME2's influence extends across cellular metabolic processes and immune regulation, underscoring its importance in tumor biology and potential therapeutic applications.