METRNL Antibody, Biotin conjugated

Code CSB-PA731035LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) METRNL Polyclonal antibody
Uniprot No.
Target Names
METRNL
Alternative Names
Meteorin like glial cell differentiation regulator antibody; Meteorin; glial cell differentiation regulator like antibody; Meteorin-like protein antibody; METRL_HUMAN antibody; Metrnl antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Meteorin-like protein (46-311AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
Gene References into Functions
  1. downregulation of METRNL during adipogenesis and functional induction of increased proliferation in stromal vascular fraction cells with concomitant inhibition of adipocyte differentiation may result in hypertrophic AT accumulation PMID: 27748745
  2. Overexpression of METRNL inhibited mineralized nodule formation. PMID: 27716826
  3. Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans. PMID: 26307585
  4. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
Subcellular Location
Secreted.
Protein Families
Meteorin family
Tissue Specificity
Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.
Database Links

HGNC: 27584

OMIM: 616241

KEGG: hsa:284207

STRING: 9606.ENSP00000315731

UniGene: Hs.378821

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