MNT Antibody

Code CSB-PA003261
Size US$100
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  • Western Blot analysis of A549 cells using MNT Polyclonal Antibody
  • Western Blot analysis of Jurkat cells using MNT Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
MNT
Alternative Names
bHLHd3 antibody; Class D basic helix-loop-helix protein 3 antibody; MAD6 antibody; MAX binding protein antibody; Max binding protein MNT antibody; MAX network transcriptional repressor antibody; Max-binding protein MNT antibody; Mnt antibody; MNT_HUMAN antibody; MXD6 antibody; Myc antagonist MNT antibody; Protein ROX antibody; ROX antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from the Internal region of Human MNT.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:40000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'.
Gene References into Functions
  1. In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes. PMID: 27018948
  2. The data demonstrate that the balance between c-Myc and Mnt activity determines the transcriptional outcome of the hTERT promoter by modulation of the chromatin architecture. PMID: 23860446
  3. The results suggest that MNT, via interaction with Nck1, inhibits hepatoma cell migration. PMID: 22964333
  4. downregulation MYCN was reflected in a decreased MYCN/Max DNA-binding activity while the Mnt/Max binding did not change during differentiation PMID: 15258910
  5. Serum stimulation of quiescent cells results in phosphorylation of Mnt and disruption of the critical Mnt-mSin3-HDAC1 interaction. This in turn leads to increased expression of the Myc/Mnt target gene cyclin D2. Review. PMID: 17419941

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Subcellular Location
Nucleus.
Database Links

HGNC: 7188

OMIM: 603039

KEGG: hsa:4335

STRING: 9606.ENSP00000174618

UniGene: Hs.626579

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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