MPI Antibody

Datasheet

Code	CSB-PA014754ESR1HU
Size	US$166
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Image	Western blot All lanes: MPI antibody at 5.12µg/ml Lane 1: Mouse heart tissue Lane 2: Mouse kidney tissue Lane 3: Mouse brain tissue Lane 4: HepG2 whole cell lysate Lane 5: 293T whole cell lysate Lane 6: A549 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 47, 40 kDa Observed band size: 47 kDa Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA014754ESR1HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA014754ESR1HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) MPI Polyclonal antibody

Uniprot No.

P34949

Target Names

MPI

Alternative Names

ody; CDG1B antibody; FLJ39201 antibody; Mannose 6 phosphate isomerase antibody; Mannose-6-phosphate isomerase antibody; MANNOSEPHOSPHATE ISOMERASE antibody; MGC94106 antibody; MPI antibody; MPI_HUMAN antibody; Phosphohexomutase antibody; phosphomannose isomerase 1 antibody; Phosphomannose isomerase antibody; PMI antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Mannose-6-phosphate isomerase protein (1-423AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Gene References into Functions

This work provides mechanistic evidence by which mannose phosphate isomerase loss induces p53, and identifies mannose phosphate isomerase as a novel regulator of p53 and Warburg metabolism. PMID: 28644127
Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts PMID: 21949237
The mannose-6-phosphate-enzyme complex is developed and the key residues involved in the ligand binding are determined. Our results suggest a hydride transfer mechanism of alpha-hydrogen between the C1 and C2 positions. PMID: 16488169

Involvement in disease

Congenital disorder of glycosylation 1B (CDG1B)

Subcellular Location

Cytoplasm.

Protein Families

Mannose-6-phosphate isomerase type 1 family

Tissue Specificity

Expressed in all tissues, but more abundant in heart, brain and skeletal muscle.

Database Links

HGNC: 7216

OMIM: 154550

KEGG: hsa:4351

STRING: 9606.ENSP00000318318

UniGene: Hs.75694

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Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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