MUC1 Antibody

Code CSB-PA015215GA01HU
Product Type Purified Rabbit Anti Human PolyClonal Antibody
Size US$685
Uniprot No. P15941
Immunogen Human CA15-3,MUC1
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA,WB,IHC
Storage Buffer PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method Antigen Affinity purified
Isotype IgG
Alias mucin 1, cell surface associated;MUC1;CD227;EMA;H23AG;MAM6;PEM;PEMT;PUM ;MUC1
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Research Area Signal Transduction
Target Names MUC1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Details This gene is a member of the mucin family and encodes a membrane bound, glycosylated phosphoprotein. The protein is anchored to the apical surface of many epithelia by a transmembrane domain, with the degree of glycosylation varying with cell type. It also includes a 20 aa variable number tandem repeat (VNTR) domain, with the number of repeats varying from 20 to 120 in different individuals. The protein serves a protective function by binding to pathogens and also functions in a cell signaling capacity. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. Multiple alternatively spliced transcript variants that encode different isoforms of this gene have been reported, but the full-length nature of only some has been determined.
HGNC 7508
RGD 3122
MGI 97231
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Function The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.; FUNCTION
Involvement in disease Medullary cystic kidney disease 1 (MCKD1)
Subcellular Location Apical cell membrane, Single-pass type I membrane protein, Note=Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells, After endocytosis, internalized and recycled to the cell membrane, Located to microvilli and to the tips of long filopodial protusions, SUBCELLULAR LOCATION: Isoform 5: Secreted, SUBCELLULAR LOCATION: Isoform Y: Secreted, SUBCELLULAR LOCATION: Isoform 9: Secreted, SUBCELLULAR LOCATION: Mucin-1 subunit beta: Cell membrane, Cytoplasm, Nucleus
Tissue Specificity Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tum
Database Links

HGNC: 7508

OMIM: 113720

KEGG: hsa:4582

STRING: 9606.ENSP00000357380

UniGene: Hs.89603

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