NEK9 Antibody, Biotin conjugated

Code CSB-PA837435LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NEK9 Polyclonal antibody
Uniprot No.
Target Names
NEK9
Alternative Names
KIAA1995 antibody; APUG antibody; DKFZp434D0935 antibody; LCCS10 antibody; MGC138306 antibody; MGC16714 antibody; NC antibody; NEK 9 antibody; Nek8 antibody; nek9 antibody; NEK9_HUMAN antibody; Nercc 1 kinase antibody; NERCC antibody; NERCC1 antibody; Nercc1 kinase antibody; Never in mitosis A related kinase 9 antibody; Never in mitosis A-related kinase 9 antibody; NIMA (never in mitosis gene a) related kinase 9 antibody; NIMA related kinase 8 antibody; NIMA related kinase 9 antibody; NIMA related kinase Nek8 antibody; NimA related protein kinase 9 antibody; NIMA-related kinase 8 antibody; NimA-related protein kinase 9 antibody; Serine/threonine protein kinase Nek9 antibody; Serine/threonine-protein kinase Nek9 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Serine/threonine-protein kinase Nek9 protein (821-979AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively.
Gene References into Functions
  1. High expression level of NEK9 is associated with recurrence in glioblastoma. PMID: 26956052
  2. Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7, and Nek9 is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 and Kif14 to properly coordinate cytokinesis. PMID: 28630147
  3. Recessive NEK9 mutation is associated with lethal skeletal dysplasia. PMID: 26908619
  4. Somatic Mutations in NEK9 Cause Nevus Comedonicus. PMID: 27153399
  5. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 target gene expression. PMID: 26676776
  6. The C-terminal domain of Nek9 activates Nek7 through promoting back-to-back dimerization. PMID: 26522158
  7. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53. PMID: 25131192
  8. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint control. PMID: 23665325
  9. Structural analysis of LC8 with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 upon phosphorylation on Ser(944) within the Nek9 sequence PMID: 23482567
  10. Nek9 phosphorylates NEDD1 on Ser377 driving its recruitment and thereby that of gamma-tubulin to the centrosome in mitotic cells. PMID: 22818914
  11. The interaction between the human NimA-like protein kinase Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance. PMID: 21735226
  12. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5. PMID: 21642957
  13. DYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9. PMID: 21454704
  14. binds the Ran GTPase and regulates mitotic progression PMID: 12101123
  15. Activated in mitosis, and activates nek6 and nek7 kinase. PMID: 12840024
  16. mediates certain cellular processes, which are ultimately essential for interphase progression PMID: 14660563
  17. The disruption of a nuclear function of NEK9 by adenovirus E1A-associated cellular proteins is reported. PMID: 17443675
  18. The activity of Nek6 and Nek7, but not the tyrosine mutant, is increased by interaction with the Nek9 noncatalytic C-terminal domain, suggesting a mechanism in which the tyrosine is released from its autoinhibitory position. PMID: 19941817

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Involvement in disease
Lethal congenital contracture syndrome 10 (LCCS10); Nevus comedonicus (NC); Arthrogryposis, Perthes disease, and upward gaze palsy (APUG)
Subcellular Location
Cytoplasm. Nucleus.
Protein Families
Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Tissue Specificity
Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and fibroblasts.
Database Links

HGNC: 18591

OMIM: 609798

KEGG: hsa:91754

STRING: 9606.ENSP00000238616

UniGene: Hs.624721

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