NGFR Antibody

Datasheet
Code CSB-PA003448
Size US$167
Uniprot No. P08138
Image
  • Western Blot analysis of HepG2 cells using NGFR p75 Polyclonal Antibody
  • Western Blot analysis of K562 cells using NGFR p75 Polyclonal Antibody
Protocols Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
ELISA Protocol
Immunogen Synthesized peptide derived from the Internal region of Human NGFR p75.
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications WB,IF,ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/40000
Form Liquid
Conjugate Non-conjugated
Storage Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Alias NGFR; TNFRSF16; Tumor necrosis factor receptor superfamily member 16; Gp80-LNGFR; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; NGF receptor; p75 ICD; CD antigen CD271
Immunogen Species Homo sapiens (Human)
Target Names NGFR
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
References
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Function Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Subcellular Location Membrane, Single-pass type I membrane protein
Database Links

HGNC: 7809

OMIM: 162010

KEGG: hsa:4804

STRING: 9606.ENSP00000172229

UniGene: Hs.415768

Pathway MAPK signaling pathway
PI3K-Akt signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Neurotrophin signaling pathway

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