Recombinant Human Tumor necrosis factor receptor superfamily member 16 (NGFR), partial

Code CSB-YP015780HU
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Source Yeast
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Code CSB-EP015780HU
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Source E.coli
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Code CSB-EP015780HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015780HU
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Source Baculovirus
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Code CSB-MP015780HU
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
CD271; CD271 antigen; Gp80 LNGFR; Gp80-LNGFR; Low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Nerve growth factor receptor; Nerve growth factor receptor TNFR superfamily member 16; NGF receptor; Ngfr; p75 ICD; p75 Neurotrophin receptor; p75 NTR; p75(NTR); p75NTR; TNFR Superfamily Member 16; TNFRSF16; TNR16_HUMAN; Tumor necrosis factor receptor superfamily member 16
Homo sapiens (Human)
Expression Region
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF. Plays an important role in differentiation and survival of specific neuronal populations during development. Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA. Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver.
Gene References into Functions
  1. results demonstrate that cells with in vitro ASC traits can be obtained from both CD271(+) and CD271(-) stromal populations of human adipose tissue. In addition, gene expression profiling and in situ localization analyses indicate that the CD271(+) population displays a pericytic phenotype. PMID: 29125884
  2. loss of epidermal CD271(+) keratinocytes seemed necessary for melanoma development PMID: 29678478
  3. Cleaved intracellular domain of CD271 controls proliferation, while the interaction of CD271 with the neurotrophin receptor Trk-A modulates cell adhesiveness through dynamic regulation of a set of cholesterol synthesis genes relevant for patient survival. PMID: 29215016
  4. Results show that glioma cells with p75NTR overexpression demonstrated certain unique characteristics of tumor-initiating cells, such as neurosphere formation, high colony proliferation, and resistance to radiotherapy and chemotherapy. PMID: 30194166
  5. we found good intra-class correlation in CD271 + MSC score among individual pathologists, with excellent performance by the group as a whole. Prospective studies of CD271 + MSC density are necessary to corroborate its diagnostic and prognostic utility. PMID: 27808583
  6. High p75(NTR) expression is associated with esophageal squamous cell carcinoma. PMID: 28534989
  7. Collectively, CD271 initiates tumor formation by increasing the cell proliferation capacity through CDKN1C suppression and ERK-signaling activation, and by accelerating the migration signaling pathway in hypopharyngeal cancer. PMID: 27469492
  8. Study shows that p75 pan-neurotrophin receptor is upregulated in the nerve fibers and inflammatory cells in the local tissue in inflammatory pain. PMID: 27251195
  9. Dermal CD271+ cells are closely associated with wound healing. PMID: 28127619
  10. p75NTR+ cells isolated from tongue squamous cell carcinoma (TSCC) cell lines possess the characteristics of cancer stem cells; therefore, p75NTR may be considered a useful surface marker for the identification of TSCC stem cells. PMID: 28447720
  11. This study show evidence of variation in plasmatic p75NTR receptor expression during the progression of dementia. PMID: 27802234
  12. p75(NTR) was overexpressed in anaplastic thyroid cancers compared with papillary and follicular subtypes PMID: 29037860
  13. p75NTR, mainly expressed in tumor tissues, was significantly associated with higher Fuhrman grade in multivariate analysis. these data highlight for the first time an important role for p75NTR in renal cancer and indicate a putative novel target therapy in renal cell carcinoma. PMID: 27120782
  14. Here, the authors unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly binding to its central DNA binding domain and preventing its DNA-binding activity. PMID: 27282385
  15. Data suggest that p75NTR as a central regulator of glioma tumorigenesis, the tumor microenvironment, and tumor invasiveness; p75NTR may contribute to the drug resistance of glioma. [REVIEW] PMID: 28215302
  16. These results demonstrated that EpCAM + p75NTR+ CTC count was a more accurate diagnostic marker than EpCAM+ CTC count, suggesting the highly metastatic potential of CTCs with p75NTR expression. PMID: 28560678
  17. Co-immunoprecipitation and biochemical fractionation data suggested that p75 TM stimulates TrkB phosphorylation at the cell membrane. PMID: 28821608
  18. hese results suggest that LNGFR(+)THY-1(+) cells identified following NCLC induction from ESCs/iPSCs shared similar potentials with multipotent MSCs. PMID: 27178356
  19. the results indicate that CD271 loss is critical for melanoma progression and metastasis. PMID: 27328305
  20. For Fat3, the Kif5-ID is regulated by alternative splicing, and the timecourse of splicing suggests that the distribution of Fat3 may switch between early and later stages of retinal development. In contrast, P75NTR binding to Kif5B is enhanced by tyrosine phosphorylation and thus has the potential to be dynamically regulated on a more rapid time scale PMID: 27788242
  21. p75(NTR) and NIX may play critical roles in intracerebral hemorrhage-induced neuronal apoptosis in vitro and in vivo. PMID: 27726026
  22. The results of this study suggest that p75(+) hDPSC may denote a subpopulation with greater neurogenic potential in human dental pulp stem cells. PMID: 27469433
  23. here for the first time, hsa-miR-939 is introduced as a novel key regulator of NGFR expression and its involvement in cell death/survival processes is suggested. PMID: 28229962
  24. The receptors p75 and TrkB are more highly expressed in deep infiltrating endometriosis than in peritoneal tissues. PMID: 27519317
  25. e disappearance of the superiority in tumorigenicity in vitro and vivo in CD271+ OS cells. CONCLUSION: The results above demonstrated that autophagy contributes to the stem-like features of CD271+ OS CSCs. Inhibition of autophagy is a promising strategy in the CSCs-targeting OS therapy. PMID: 27863492
  26. hA17-29 aggregate toxicity seems to be mediated by RAGE and p75-NGFR receptors PMID: 27804051
  27. Results revealed that most of the p75NTR-positive cells were in a mitotically quiescent state, while the majority of the p75NTR-negative cells were actively proliferating in esophageal squamous cell carcinoma. PMID: 26984177
  28. Data show that under reducing conditions, p75 neurotrophin receptor transmembrane (TM) domain (p75-TM-WT) is in a monomer-dimer equilibrium with the cysteine (Cys 257) residue located on the dimer interface. PMID: 27056327
  29. p75NTR and CRABP1 modulate the effect of fenretinide on neuroblastoma cells PMID: 26843908
  30. Identify a novel signaling pathway in hepatocytes triggered by ligand-activated p75NTR that via p38 MAPK and caspase-3 mediate the activation of SREBP2. This pathway may regulate LDLRs and lipid uptake particularly after injury or during tissue inflammation accompanied by an increased production of growth factors, including NGF and pro-NGF. PMID: 26984409
  31. Studies indicate that neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction. PMID: 26700963
  32. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I-II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III-IV). PMID: 26408608
  33. High p75NTR expression is associated with esophageal cancer. PMID: 26897248
  34. RIP2 and RhoGDI bind to p75(NTR) death domain at partially overlapping epitopes with over 100-fold difference in affinity, revealing the mechanism by which RIP2 recruitment displaces RhoGDI upon ligand binding. PMID: 26646181
  35. preventing phosphorylation of p75(NTR) by pharmacological inhibition of PKA, or by a mutational strategy, cripples p75(NTR)-mediated glioma invasion resulting in serine phosphorylation within the C-terminal PDZ-binding motif (SPV) of p75(NTR). PMID: 26119933
  36. NGFR Ser205Leu polymorphism modulates the autonomic vagal outflow to the heart, particularly in men. PMID: 26278479
  37. Findings show no association of SNPs in NTRK2 and NGFR genes with completed suicide in Slovenian population. PMID: 26462037
  38. expression of HIF-1alpha and CD271 in melanomas at different phases of progression, as evaluated by histology and reflectance confocal microscopy PMID: 25739328
  39. there are 15 positive studies among 30 studies regarding BDNF/TRKB/P75NTR polymorphisms antidepressant efficacy in depressed patients--{REVIEW} PMID: 26122862
  40. The ATF4/p75NTR/IL-8 signal pathway may have an important role in EndoMT induced by SFO. PMID: 24905361
  41. Data indicate that p75 neurotrophin receptor p75(NTR) could be a potential therapeutic target for retinal pigment epithelium (RPE) hypoxia or oxidative stress diseases. PMID: 25200140
  42. p75(NTR) and alpha9 integrin subunit are not closely associated through their cytoplasmic domains, most probably because of the molecular interference with other cytoplasmic proteins such as paxillin. PMID: 25748048
  43. Activation of p75NTR receptor identified that the receptor predominantly assembles as a trimer in brain tissue. PMID: 26311773
  44. CD271 expression is associated with stage and lymph node metastasis in esophageal squamous cell carcinoma specimens.Epigenetic regulation of CD271 is associated with chemoresistance and metastatic capacity in esophageal squamous cell carcinoma. PMID: 25351876
  45. p75NGFR is a candidate tumor suppressor and has independent prognostic potential in colorectal cancer. PMID: 25244921
  46. Case Report: strong p75 staining in cutaneous squamous cell carcinoma. PMID: 25321086
  47. Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR). PMID: 25666623
  48. Therefore, the 12 selected SNPs may act as tag SNPs for the entire p75NTR gene in Chinese Han population. PMID: 25227100
  49. data strongly suggest that CD271 is a crucial determinant of stem-like properties of melanoma cells like colony-formation and tumorigenicity. PMID: 24799129
  50. Data are the first to demonstrate that CD271 more specifically identifies the TIC subpopulation within the CD44+ compartment in SCCHN and that this receptor is a functionally active and targetable molecule. PMID: 25149537

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Perikaryon. Cell projection, growth cone. Cell projection, dendritic spine.
Database Links

HGNC: 7809

OMIM: 162010

KEGG: hsa:4804

STRING: 9606.ENSP00000172229

UniGene: Hs.415768

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