NMUR2 Antibody

Code CSB-PA135689
Size US$100
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  • Western Blot analysis of mouse-brain cells using primary antibody diluted at 1:2000(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour)
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Product Details

Uniprot No.
Target Names
NMUR2
Alternative Names
NMUR2; NMU2R; TGR1; Neuromedin-U receptor 2; NMU-R2; G-protein coupled receptor FM-4; G-protein coupled receptor TGR-1
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from Human NMUR2. at AA range: 1-50
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB,ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-2000
ELISA 1:10000-20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Receptor for the neuromedin-U and neuromedin-S neuropeptides.
Gene References into Functions
  1. NMU might contribute to progression of NMUR2-positive breast cancer PMID: 28423716
  2. polymorphisms in the gene may be useful in identifying women at risk for osteoporosis. PMID: 25871004
  3. Study identified a novel NMUR2 splice variant lacking the third exon and able to form heteromeric complexes with NMUR1 and NMUR2 without Neuromedin U (NMU). Its expression can block NMU signaling suppressing then ovarian cancer cells proliferation. PMID: 26317338
  4. A cell-based reporter gene assay has been developed and used for the screening of the human NMU2R agonist. PMID: 16781063
Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 1 family
Tissue Specificity
Predominantly expressed in the CNS, particularly in the medulla oblongata, pontine reticular formation, spinal cord, and thalamus. High level in testis whereas lower levels are present in a variety of peripheral tissues including the gastrointestinal trac
Database Links

HGNC: 16454

OMIM: 605108

KEGG: hsa:56923

STRING: 9606.ENSP00000255262

UniGene: Hs.731911

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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