NOG Antibody

Datasheet
Code CSB-PA931108
Size US$167
Uniprot No. Q13253
Image
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
Immunogen Synthetic peptide from Human protein at AA range: 21-70
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Tested Applications IHC,ELISA;IHC-p:1:50-300,ELISA:1:10000-20000
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Purification Method The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Alias Noggin
Immunogen Species Homo sapiens (Human)
Protocols Immunohistochemistry (IHC) Protocol
ELISA Protocol
Target Names NOG
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6
Involvement in disease Symphalangism, proximal 1A (SYM1A); Multiple synostoses syndrome 1 (SYNS1); Tarsal-carpal coalition syndrome (TCC); Stapes ankylosis with broad thumb and toes (SABTS); Brachydactyly B2 (BDB2)
Subcellular Location Secreted
Protein Families Noggin family
Database Links

HGNC: 7866

OMIM: 184460

KEGG: hsa:9241

STRING: 9606.ENSP00000328181

UniGene: Hs.248201

Pathway TGF-beta signaling pathway

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