Recombinant Human Noggin protein(NOG) (Active)

In Stock
Code CSB-AP003011HU
Product Type Growth Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q13253
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered 30 % acetonitrile, 0.1 % TFA ,lyophilized
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of >3.3x105 IU/mg in the presence of 5 ng/ml rHuBMP-4.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Research Area Stem Cells?
Source E.coli
Gene Names NOG
Expression Region 28-232aa
Tag Info Tag-Free
Mol. Weight 46.3 kDa
Protein Description Full Length of Mature Protein
PubMed ID 7666191; 15489334; 21976273; 24098149; 12478285; 10080184; 11846737; 11545688; 12089654; 11857750; 15770128; 17668388; 20503332
Still Have Questions? Leave a Message or Start an on-line Chat
Function Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6
Involvement in disease Symphalangism, proximal 1A (SYM1A); Multiple synostoses syndrome 1 (SYNS1); Tarsal-carpal coalition syndrome (TCC); Stapes ankylosis with broad thumb and toes (SABTS); Brachydactyly B2 (BDB2)
Subcellular Location Secreted
Protein Families Noggin family
Database Links

HGNC: 7866

OMIM: 184460

KEGG: hsa:9241

STRING: 9606.ENSP00000328181

UniGene: Hs.248201

Pathway TGF-beta signaling pathway

Related Products

NOG Antibodies

NOG Antibodies for Homo sapiens (Human)

NOG Antibodies for Human

NOG Proteins

NOG Proteins for Homo sapiens (Human)

NOG ELISA Kit

NOG ELISA Kit for Homo sapiens (Human)

Most popular with customers

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

Copyright © 2007-2018 www.cusabio.com CUSABIO TECHNOLOGY LLC All Rights Reserved.

Wait!

Join the 20,000 subscribers to get research hotpots, technical tips, latest information on events, sales and offers.

Sign up now to get your $50 coupon for protein expression service!

We don't deal in spam.