NP Antibody

Code CSB-PA361330LA01IJK
Size US$166
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Product Details

Full Product Name
Rabbit anti-Influenza B virus NP Polyclonal antibody
Uniprot No.
Target Names
NP
Alternative Names
NP antibody; Nucleoprotein antibody; Nucleocapsid protein antibody; Protein N antibody
Raised in
Rabbit
Species Reactivity
Influenza B virus
Immunogen
Recombinant Influenza B virus Nucleoprotein protein (1-560AA)
Immunogen Species
Influenza B virus
Conjugate
Non-conjugated

The NP Antibody (Product code: CSB-PA361330LA01IJK) is Non-conjugated. For NP Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA361330LB01IJK NP Antibody, HRP conjugated ELISA
FITC CSB-PA361330LC01IJK NP Antibody, FITC conjugated
Biotin CSB-PA361330LD01IJK NP Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Gene References into Functions
  1. Results show that the N terminus is involved in the formation of both higher homo-oligomers of BNP and BNP-RNA complex. PMID: 26368391
Subcellular Location
Virion. Host nucleus.
Protein Families
Influenza viruses nucleoprotein family
Database Links

KEGG: vg:26824002

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