NPRL3 Antibody, HRP conjugated

Datasheet
Code CSB-PA619643LB01HU
Size US$299
Uniprot No. Q12980
Protocols ELISA Protocol
Immunogen Recombinant Human GATOR complex protein NPRL3 protein (349-482AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Form Liquid
Conjugate HRP
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias GATOR complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA), NPRL3, C16orf35 CGTHBA MARE
Immunogen Species Homo sapiens (Human)
Research Area Signal Transduction
Target Names NPRL3
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
Involvement in disease Epilepsy, familial focal, with variable foci 3 (FFEVF3)
Subcellular Location Lysosome membrane
Protein Families NPR3 family
Tissue Specificity Widely expressed. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888).
Database Links

HGNC: 14124

OMIM: 600928

KEGG: hsa:8131

STRING: 9606.ENSP00000382834

UniGene: Hs.19699

Pathway mTOR signaling pathway

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