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GATOR complex protein NPRL3 is a protein in humans that is encoded by NPRL3 gene. As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.
The following NPRL3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NPRL3 Antibodies for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA893330XA01DLU | Nprl3 Antibody |
Drosophila melanogaster (Fruit fly) | ELISA, WB (ensure identification of antigen) |
NPRL3 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA619643LA01HU | NPRL3 Antibody |
Human | ELISA, WB, IHC |
| CSB-PA619643LB01HU | NPRL3 Antibody, HRP conjugated |
Human | ELISA |
| CSB-PA619643LC01HU | NPRL3 Antibody, FITC conjugated |
Human | |
| CSB-PA619643LD01HU | NPRL3 Antibody, Biotin conjugated |
Human | ELISA |
NPRL3 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP619643HU CSB-EP619643HU CSB-BP619643HU CSB-MP619643HU CSB-EP619643HU-B |
Recombinant Human Nitrogen permease regulator 3-like protein (NPRL3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPRL3 Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP840880MO CSB-EP840880MO CSB-BP840880MO CSB-MP840880MO CSB-EP840880MO-B |
Recombinant Mouse Nitrogen permease regulator 3-like protein (Nprl3) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPRL3 Proteins for Drosophila melanogaster (Fruit fly)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP893330DLU CSB-EP893330DLU CSB-BP893330DLU CSB-MP893330DLU CSB-EP893330DLU-B |
Recombinant Drosophila melanogaster Nitrogen permease regulator 3-like protein (CG8783), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
