NREP Antibody

Datasheet

Code	CSB-PA620971LA01HU
Size	US$166
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Image	IHC image of CSB-PA620971LA01HU diluted at 1:600 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. Immunofluorescence staining of SH-SY5Y cells with CSB-PA620971LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NREP Polyclonal antibody

Uniprot No.

Q16612

Target Names

NREP

Alternative Names

3.1 gene antibody; C5orf13 antibody; Chromosome 5 open reading frame 13 antibody; D4S114 antibody; Neuronal protein 3.1 antibody; Neuronal regeneration related protein antibody; Neuronal regeneration related protein homolog (rat) antibody; Neuronal regeneration related protein homolog antibody; NP311_HUMAN antibody; NREP antibody; P311 antibody; PRO1873 antibody; Protein p311 antibody; PTZ17 antibody; SEZ17 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Neuronal regeneration-related protein (1-68AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NREP Antibody (Product code: CSB-PA620971LA01HU) is Non-conjugated. For NREP Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA620971LB01HU	NREP Antibody, HRP conjugated	ELISA
FITC	CSB-PA620971LC01HU	NREP Antibody, FITC conjugated
Biotin	CSB-PA620971LD01HU	NREP Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:500-1:1000
IF	1:200-1:500

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May have roles in neural function. Ectopic expression augments motility of gliomas. Promotes also axonal regeneration. May also have functions in cellular differentiation. Induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation.

Gene References into Functions

P311 is a novel TGFbeta1/Smad signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing. PMID: 27906099
P311 could accelerate skin wound reepithelialization by promoting the migration of Epidermal Stem Cell through RhoA and Rac1 activation. PMID: 27927130
These studies demonstrate that P311 is required for the production of normal cutaneous scars PMID: 27939132
P311 plays a key role in renal fibrosis via TGFbeta1/Smad signaling, which could be a novel target for the management of renal fibrosis. PMID: 26616407
P311 may promote the migration of ESCs both in micewith superficial partial-thickness burns and in an injured cell model in vitro, and it may play an important role in wound healing. PMID: 22967977
Protein HYI may closely bind with protein P311 by an alpha helix in hypertrophic scar fibroblasts. PMID: 22490543
P311 and ITGB4BP expression was elevated in non-small cell lung cancer, possibly indicative of a new signaling pathway. PMID: 21029697
P311 may be involved in the pathogenesis of hypertrophic scar via induction of a myofibrobla PMID: 20404911
role for P311 in inducing TGF-beta1-independent myofibroblast transformation PMID: 12417574
These results suggest a role for levels of P311 in regulating glioma motility and invasion through the reorganization of actin cytoskeleton at the cell periphery. PMID: 16229809
P311 expression is tightly regulated during the critical periods of alveolar formation, and that under pathologic conditions, its relative absence may contribute to failure of alveolar regeneration and lead to the development of human emphysema. PMID: 16484684

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Subcellular Location

Cytoplasm.

Tissue Specificity

Expressed in lung (at protein level).

Database Links

HGNC: 16834

OMIM: 607332

KEGG: hsa:9315

UniGene: Hs.36053

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DNA Damage and Repair Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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