NRG2 Antibody, FITC conjugated

Datasheet

Code	CSB-PA016078LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NRG2 Polyclonal antibody

Uniprot No.

O14511

Target Names

NRG2

Alternative Names

Divergent of neuregulin 1 antibody; Divergent of neuregulin-1 antibody; Don 1 antibody; DON-1 antibody; Neural- and thymus-derived activator for ERBB kinases antibody; Neuregulin 2 antibody; Neuregulin-2 antibody; NRG-2 antibody; Nrg2 antibody; NRG2_HUMAN antibody; NTAK antibody; Pro NRG2 antibody; Pro-NRG2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pro-neuregulin-2, membrane-bound isoform protein (112-405AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

Gene References into Functions

reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
examination of the effect of isoforms on angiogenesis PMID: 14722120
Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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Subcellular Location

[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.

Protein Families

Neuregulin family

Tissue Specificity

Restricted to the cerebellum in the adult.

Database Links

HGNC: 7998

OMIM: 603818

KEGG: hsa:9542

STRING: 9606.ENSP00000354910

UniGene: Hs.408515

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Protein Service

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Related pathways

ErbB signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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