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Human neuregulin-2 (NRG2) ELISA kit

Citations (1) Protocol MSDS
Code CSB-EL016078HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
neuregulin-2 (NRG2)
Alternative Names
Divergent of neuregulin 1 ELISA Kit; Divergent of neuregulin-1 ELISA Kit; Don 1 ELISA Kit; DON-1 ELISA Kit; Neural- and thymus-derived activator for ERBB kinases ELISA Kit; Neuregulin 2 ELISA Kit; Neuregulin-2 ELISA Kit; NRG-2 ELISA Kit; Nrg2 ELISA Kit; NRG2_HUMAN ELISA Kit; NTAK ELISA Kit; Pro NRG2 ELISA Kit; Pro-NRG2 ELISA Kit
Abbreviation
NRG2
Uniprot No.
O14511
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
31.25 pg/mL-2000 pg/mL
Sensitivity
7.81 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Neuroscience
Assay Principle
quantitative
Measurement
Sandwich
Precision
Intra-assay Precision (Precision within an assay): CV%<8%        
Three samples of known concentration were tested twenty times on one plate to assess.    
Inter-assay Precision (Precision between assays): CV%<10%        
Three samples of known concentration were tested in twenty assays to assess.      
               
Linearity
To assess the linearity of the assay, samples were spiked with high concentrations of human NRG2 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.  
　 Sample Serum(n=4)    
1:5 Average % 101    
Range % 88-105    
1:10 Average % 100    
Range % 90-105    
1:20 Average % 97    
Range % 88-101    
1:40 Average % 99    
Range % 94-102    
Recovery
The recovery of human NRG2 spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.  
 
Sample Type Average % Recovery Range    
Serum (n=5) 94 87-97    
EDTA plasma (n=4) 101 95-107    
               
               
Typical Data
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.  
 
pg/ml OD1 OD2 Average Corrected    
2000 2.638 2.567 2.603 2.404    
1000 2.312 2.222 2.267 2.068    
500 1.722 1.787 1.755 1.556    
250 1.156 1.129 1.143 0.944    
125 0.702 0.684 0.693 0.494    
62.5 0.501 0.513 0.507 0.308    
31.25 0.326 0.338 0.332 0.133    
0 0.201 0.197 0.199 　    
ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Shelf Life
6 months
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx.
Description

This Human NRG2 ELISA Kit was designed for the quantitative measurement of Human NRG2 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

Citations

Related Products

NRG2 Antibodies

NRG2 Proteins

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Target Background

Function
(From Uniprot)
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Gene References into Functions
  1. reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
  2. examination of the effect of isoforms on angiogenesis PMID: 14722120
  3. Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
  4. Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
  5. Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
  6. NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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Subcellular Location
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
Protein Families
Neuregulin family
Tissue Specificity
Restricted to the cerebellum in the adult.
Database Links

HGNC: 7998

OMIM: 603818

KEGG: hsa:9542

STRING: 9606.ENSP00000354910

UniGene: Hs.408515

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Related pathways
ErbB signaling pathway
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