NRG2 Antibody

Code CSB-PA005145
Size US$100
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  • Western Blot analysis of HT29 cells using Neuregulin-2 Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
NRG2
Alternative Names
Divergent of neuregulin 1 antibody; Divergent of neuregulin-1 antibody; Don 1 antibody; DON-1 antibody; Neural- and thymus-derived activator for ERBB kinases antibody; Neuregulin 2 antibody; Neuregulin-2 antibody; NRG-2 antibody; Nrg2 antibody; NRG2_HUMAN antibody; NTAK antibody; Pro NRG2 antibody; Pro-NRG2 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from the Internal region of Human Neuregulin-2.
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Isotype
IgG
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
WB, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
ELISA 1:20000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Gene References into Functions
  1. reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
  2. examination of the effect of isoforms on angiogenesis PMID: 14722120
  3. Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
  4. Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
  5. Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
  6. NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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Subcellular Location
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
Protein Families
Neuregulin family
Tissue Specificity
Restricted to the cerebellum in the adult.
Database Links

HGNC: 7998

OMIM: 603818

KEGG: hsa:9542

STRING: 9606.ENSP00000354910

UniGene: Hs.408515

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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