NRG2 Antibody

Code CSB-PA016078LA01HU
Size US$166
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  • Western blot
    All lanes: NRG2 antibody at 16µg/ml + U251 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 92, 91, 93, 47, 46, 68, 71 kDa
    Observed band size: 92 kDa

  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA016078LA01HU at dilution of 1:100

  • Immunofluorescent analysis of PC-3 cells using CSB-PA016078LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NRG2 Polyclonal antibody
Uniprot No.
Target Names
NRG2
Alternative Names
Divergent of neuregulin 1 antibody; Divergent of neuregulin-1 antibody; Don 1 antibody; DON-1 antibody; Neural- and thymus-derived activator for ERBB kinases antibody; Neuregulin 2 antibody; Neuregulin-2 antibody; NRG-2 antibody; Nrg2 antibody; NRG2_HUMAN antibody; NTAK antibody; Pro NRG2 antibody; Pro-NRG2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pro-neuregulin-2, membrane-bound isoform protein (112-405AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NRG2 Antibody (Product code: CSB-PA016078LA01HU) is Non-conjugated. For NRG2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA016078LB01HU NRG2 Antibody, HRP conjugated ELISA
FITC CSB-PA016078LC01HU NRG2 Antibody, FITC conjugated
Biotin CSB-PA016078LD01HU NRG2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.
Gene References into Functions
  1. reduced expression of NRG2 led to marginal increase in cell survival under arsenite-induced stress. PMID: 27345716
  2. examination of the effect of isoforms on angiogenesis PMID: 14722120
  3. Nrg-2-induced Acetylcholine Receptor transcription requires an N-box motif and is regulated by alternative splicing. PMID: 15961242
  4. Linkage interval for GLC1M was refined to a smaller region. The NRG2 gene was excluded as the causative gene for juvenile-onset primary open angle glaucoma. PMID: 17563728
  5. Gln43 of NRG2beta is both necessary and sufficient for NRG2 stimulation of ErbB4 coupling to IL3 independence. PMID: 17945187
  6. NRG2 was positive in almost all breast cancers studied. High expression is related to the biological aggressiveness of breast cancer. PMID: 17962208

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Subcellular Location
[Pro-neuregulin-2, membrane-bound isoform]: Cell membrane; Single-pass type I membrane protein.; [Neuregulin-2]: Secreted.
Protein Families
Neuregulin family
Tissue Specificity
Restricted to the cerebellum in the adult.
Database Links

HGNC: 7998

OMIM: 603818

KEGG: hsa:9542

STRING: 9606.ENSP00000354910

UniGene: Hs.408515

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