NT5C1A Antibody

Code CSB-PA071901
Size US$297
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  • Western blot analysis of extracts from MCF-7 cells and HepG2 cells, using NT5C1A antibody.
  • Immunofluorescence analysis of A549 cells, using NT5C1A antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NT5C1A Polyclonal antibody
Uniprot No.
Target Names
NT5C1A
Alternative Names
5' nucleotidase cytosolic IA antibody; 5NT1A_HUMAN antibody; AMP specific 5' NT antibody; CN I antibody; CN IA antibody; cN-I antibody; cN-IA antibody; CN1 antibody; cN1A antibody; cNI antibody; cNIA antibody; Cytosolic 5' nucleotidase 1A antibody; Cytosolic 5' nucleotidase IA antibody; Cytosolic 5' nucleotidase type 1A antibody; Cytosolic 5''-nucleotidase 1A antibody; Cytosolic 5''-nucleotidase IA antibody; MGC119199 antibody; MGC119201 antibody; NT5C1A antibody; nucleotidase; 5-prime; cytosolic; IA antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human NT5C1A.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:200
IF 1:100-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene References into Functions
  1. Individual missense changes in NT5C1A showed considerable variation in response to the different nucleoside analogs tested. PMID: 26906009
  2. seropositivity to the NT5c1A antibody is associated with greater motor and functional disability in sporadic inclusion body myositis PMID: 25857661
  3. Anti-NT5C1A is a common target of circulating autoantibodies in autoimmune diseases. PMID: 25892010
  4. NT5C1A suppression promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle PMID: 21873433
  5. overexpression of 5'-nucleotidase inhibits Natural Killer cell cytotoxicity to ameliorate rejection after xenotransplantation PMID: 15888028
  6. deoxycytidine kinase, deoxyguanosine kinase, and cytosolic 5'-nucleotidase I are regulated in a cell cycle-dependent manner in MOLT-4 cells PMID: 17065091
  7. There was no correlation between expression of cN-I and fiber type. PMID: 19352542

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Subcellular Location
Cytoplasm.
Protein Families
5'-nucleotidase type 3 family
Tissue Specificity
Highly expressed in skeletal muscle. Detected at intermediate levels in heart, brain, kidney and pancreas.
Database Links

HGNC: 17819

OMIM: 610525

KEGG: hsa:84618

STRING: 9606.ENSP00000235628

UniGene: Hs.307006

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