OLIG1 Antibody

Code CSB-PA016328YA01HU
Size US$166
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  • Western Blot
    Positive WB detected in: THP-1 whole cell lysate, Rat brain tissue, Rat lung tissue, Mouse spleen tissue, Mouse brain tissue
    All lanes: OLIG1 antibody at 2.8µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 28 kDa
    Observed band size: 28 kDa

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) OLIG1 Polyclonal antibody
Uniprot No.
Target Names
OLIG1
Alternative Names
Basic domain helix loop helix protein class B 6 antibody; Basic domain helix loop helix protein class B6 antibody; BHLH B6 antibody; BHLHB 6 antibody; bHLHb6 antibody; bHLHe21 antibody; Class B basic helix-loop-helix protein 6 antibody; Class E basic helix-loop-helix protein 21 antibody; Olig 1 antibody; Olig1 antibody; OLIG1_HUMAN antibody; Oligo 1 antibody; Oligo1 antibody; Oligodendrocyte lineage transcription factor 1 antibody; Oligodendrocyte specific bHLH transcription factor 1 antibody; Oligodendrocyte transcription factor 1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Oligodendrocyte transcription factor 1 protein (17-105AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The OLIG1 Antibody (Product code: CSB-PA016328YA01HU) is Non-conjugated. For OLIG1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA016328YB01HU OLIG1 Antibody, HRP conjugated ELISA
FITC CSB-PA016328YC01HU OLIG1 Antibody, FITC conjugated
Biotin CSB-PA016328YD01HU OLIG1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
Gene References into Functions
  1. Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin. PMID: 28253550
  2. This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
  3. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
  4. This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
  5. Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance. PMID: 21446039
  6. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
  7. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
  8. identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis PMID: 16820418
  9. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
  10. OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients PMID: 17388669
  11. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression. PMID: 17690840

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Subcellular Location
Nucleus.
Tissue Specificity
Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
Database Links

HGNC: 16983

OMIM: 606385

KEGG: hsa:116448

STRING: 9606.ENSP00000371785

UniGene: Hs.56663

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