OPCML Antibody

Code CSB-PA621799LA01HU
Size US$299
Image
  • Western Blot
    Positive WB detected in: U87 whole cell lysate, PC-3 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate
    All lanes: OPCML antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 39, 38, 34 kDa
    Observed band size: 39 kDa
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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) OPCML Polyclonal antibody
Uniprot No. Q14982
Target Names OPCML
Alternative Names GM181 antibody; IgLON family member 1 antibody; IGLON1 antibody; OBCAM antibody; OPCM antibody; OPCM_HUMAN antibody; OPCML antibody; Opiate binding cell adhesion molecule antibody; Opioid binding cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule antibody; Opioid binding protein/cell adhesion molecule-like antibody; Opioid binding protein/cell adhesion molecule-like preprotein antibody; Opioid-binding cell adhesion molecule antibody; Opioid-binding protein/cell adhesion molecule antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Opioid-binding protein/cell adhesion molecule protein (28-322AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:1000-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Data

Function Binds opioids in the presence of acidic lipids; probably involved in cell contact.
Gene References into Functions
  1. Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines PMID: 28775148
  2. Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. PMID: 28407749
  3. OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci PMID: 26890304
  4. OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. PMID: 27358143
  5. the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens PMID: 25652468
  6. The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. PMID: 24616287
  7. Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. PMID: 24839818
  8. The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. PMID: 22585860
  9. A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population PMID: 21833655
  10. opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma PMID: 21273058
  11. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer PMID: 12819783
  12. Oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML. PMID: 16384911
  13. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
  14. Hypermethylation of OPCML gene is responsible for silencing and loss of suppressor function in ovarian cancer. PMID: 17159813
  15. OPCML down-regulation occurs in the majority of brain tumours tested PMID: 17239010
  16. Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
  17. loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation PMID: 18179137
  18. OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. PMID: 18584347
  19. OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. PMID: 18714356

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Involvement in disease Ovarian cancer (OC)
Subcellular Location Cell membrane, Lipid-anchor, GPI-anchor
Protein Families Immunoglobulin superfamily, IgLON family
Database Links

HGNC: 8143

OMIM: 167000

KEGG: hsa:4978

STRING: 9606.ENSP00000330862

UniGene: Hs.4817

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