OPCML Antibody

1. Here we show that, though OPCML interacts only with HER2 and not with EGFR, the interaction of OPCML with HER2 disrupts the formation of the HER2-EGFR heterodimer, and this translates into a better response to both lapatinib and erlotinib in HER2-expressing ovarian and breast cancer cell lines PMID: 28775148
2. Study revealed that reduced expression of OPCML might have a significant correlation with unfavorable tumor stage and differentiation, predict poor prognosis of patients with gastric cancer. OPCML had a tumor-suppressing activity possibly via AKT/GSK3beta signaling in gastric cancer. PMID: 28407749
3. OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci PMID: 26890304
4. OPCML plays an important role in gastric cancer, and may be a new prognostic indicator of gastric cancer. PMID: 27358143
5. the DNA methylation levels of OPCML and SFRP1 could be potential biomarkers for diagnosis of CCA with high specificity, sensitivity, and accuracy, in particular for biopsy specimens PMID: 25652468
6. The generation and cardiac phenotype of single and double heterozygous gene-targeted OPCML and Neurotrimin knockout mice. PMID: 24616287
7. Detection of OPCML hypermethylation in the serum is useful for diagnosis of ovarian carcinoma. PMID: 24839818
8. The OPCML tumor suppressor negatively regulates a specific spectrum of receptor tyrosine kinases in ovarian cancer cells by binding to their extracellular domain. PMID: 22585860
9. A strong association was found between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population PMID: 21833655
10. opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma PMID: 21273058
11. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer PMID: 12819783
12. Oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML. PMID: 16384911
13. The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer. PMID: 17109515
14. Hypermethylation of OPCML gene is responsible for silencing and loss of suppressor function in ovarian cancer. PMID: 17159813
15. OPCML down-regulation occurs in the majority of brain tumours tested PMID: 17239010
16. Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
17. loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation PMID: 18179137
18. OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene. PMID: 18584347
19. OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies. PMID: 18714356

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HGNC: 8143

OMIM: 167000

KEGG: hsa:4978

STRING: 9606.ENSP00000330862

UniGene: Hs.4817