OXCT1 Antibody

1. Crystal structure of human SCOT, providing a molecular understanding of the reported mutations based on their potential structural effects. PMID: 23420214
2. Case Report: Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency causes episodic ketoacidotic crises and no apparent symptoms between them. PMID: 20652411
3. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
4. Missense Mutations in succinyl-CoA:3-ketoacid CoA transferase is associated with Ketoacidosis. PMID: 21296660
5. Results demonstrate that h-Scot-t is a single intronless gene specifically expressed in the testis. PMID: 11756565
6. In SCOT-deficient patients retaining some residual activity, permanent ketosis may be absent. PMID: 15496607
7. A 6-bp deletion at the splice donor site of intron 1 resulted in the absence of a full-length mature SCOT mRNA with faint amounts of aberrantly spliced transcripts using a cryptic splice donor site within exon 1. PMID: 16765626
8. the R268H mutation is a ketoacidosis-causing one PMID: 17706444
9. liver-specific silencing of the SCOT gene expression may be mediated in part by its 5'-flanking sequence PMID: 18648183
10. The activities of pyruvate carboxylase (SCOT) were decreased by 65% in pancreatic islets of patients with type 2 diabetes. PMID: 19296078

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HGNC: 8527

OMIM: 245050

KEGG: hsa:5019

STRING: 9606.ENSP00000196371

UniGene: Hs.278277