PCGF6 Antibody

Datasheet

Code	CSB-PA871612LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: PC-3 whole cell lysate, MCF-7 whole cell lysate All lanes: PCGF6 antibody at 3.1μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 40, 31 kDa Observed band size: 40 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PCGF6 Polyclonal antibody

Uniprot No.

Q9BYE7

Target Names

PCGF6

Alternative Names

MBLR antibody; Mel18 and Bmi1 like RING finger protein antibody; Mel18 and Bmi1-like RING finger antibody; Pcgf6 antibody; PCGF6_HUMAN antibody; Polycomb group RING finger protein 6 antibody; RING finger protein 134 antibody; RNF134 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Polycomb group RING finger protein 6 protein (9-70AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PCGF6 Antibody (Product code: CSB-PA871612LA01HU) is Non-conjugated. For PCGF6 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA871612LB01HU	PCGF6 Antibody, HRP conjugated	ELISA
FITC	CSB-PA871612LC01HU	PCGF6 Antibody, FITC conjugated
Biotin	CSB-PA871612LD01HU	PCGF6 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity.

Gene References into Functions

Pcgf6 acts as a master regulator to maintain embryonic stem cell identity. PMID: 27247273
regulation by cell cycle-dependent phosphorylation PMID: 12167161
Thus, we did not find evidence for uniquely interacting partner proteins using this approach, but did identify four new lamin A/C interactive partners PMID: 16248985
Study shows that JARID1d and MBLR occupy human Engrailed 2 gene and regulate its expression and histone H3 lysine 4 methylation levels. PMID: 17320162
MEL-18 bound to HSF2 inhibits its sumoylation by binding to and inhibiting the activity of UBC9 enzymes in the vicinity of HSF2. PMID: 18211895
Mel-18 overexpression showed reduced glycogen synthase kinase-3beta phosphorylation, beta-catenin nuclear localization, T-cell factor/lymphoid enhancer factor promoter activity, and cyclin D1 mRNA level PMID: 18519679

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Subcellular Location

Nucleus.

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 21156

OMIM: 607816

KEGG: hsa:84108

STRING: 9606.ENSP00000358862

UniGene: Hs.335808

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Signaling pathways regulating pluripotency of stem cells

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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