PDCD2 Antibody

Datasheet

Code	CSB-PA116985
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA116985(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA116985(PDCD2 Antibody) at dilution 1/10, on the right is treated with synthetic peptide. (Original magnification: ×200) Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Hela cells, Primary antibody: CSB-PA116985(PDCD2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

Q16342

Target Names

PDCD2

Alternative Names

MGC12347 antibody; OTTHUMP00000017702 antibody; PDCD 2 antibody; Pdcd2 antibody; PDCD2 protein antibody; PDCD2_HUMAN antibody; Programmed cell death 2 antibody; Programmed cell death protein 2 antibody; RP 8 antibody; RP8 antibody; Rp8 homolog antibody; Zinc finger MYND domain containing protein 7 antibody; Zinc finger MYND domain-containing protein 7 antibody; Zinc finger protein Rp 8 antibody; Zinc finger protein Rp-8 antibody; Zinc finger protein Rp8 antibody; ZMYND 7 antibody; ZMYND7 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide of Human PDCD2

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,WB,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:5000
WB	1:200-1:1000
IHC	1:25-1:100

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Gene References into Functions

PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway. PMID: 26589942
PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells. PMID: 26617804
Low PDCD2 expression is associated with gastric cancer. PMID: 25111461
Loss of PDCD2 expression could contribute to gastric cancer development and progression. PMID: 25334010
Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. PMID: 24381196
PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse. PMID: 23760497
PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development. PMID: 22922207
Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade. PMID: 20605493
To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2. PMID: 16311922
repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas PMID: 17468402

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Subcellular Location

Nucleus.

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 8762

OMIM: 600866

KEGG: hsa:5134

STRING: 9606.ENSP00000439467

UniGene: Hs.367900

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Transmembrane Protein Questionnaire with Gifts

Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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