PDCD2 Antibody

1. PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway. PMID: 26589942
2. PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells. PMID: 26617804
3. Low PDCD2 expression is associated with gastric cancer. PMID: 25111461
4. Loss of PDCD2 expression could contribute to gastric cancer development and progression. PMID: 25334010
5. Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. PMID: 24381196
6. PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse. PMID: 23760497
7. PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development. PMID: 22922207
8. Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade. PMID: 20605493
9. To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2. PMID: 16311922
10. repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas PMID: 17468402

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HGNC: 8762

OMIM: 600866

KEGG: hsa:5134

STRING: 9606.ENSP00000439467

UniGene: Hs.367900