Recombinant Human Programmed cell death protein 2 (PDCD2)

Code CSB-YP618070HU
MSDS
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Source Yeast
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Code CSB-EP618070HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP618070HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP618070HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PDCD2
Uniprot No.
Alternative Names
MGC12347; OTTHUMP00000017702; PDCD 2; Pdcd2; PDCD2 protein; PDCD2_HUMAN; Programmed cell death 2; Programmed cell death protein 2; RP 8; RP8; Rp8 homolog; Zinc finger MYND domain containing protein 7; Zinc finger MYND domain-containing protein 7; Zinc finger protein Rp 8; Zinc finger protein Rp-8; Zinc finger protein Rp8; ZMYND 7; ZMYND7
Species
Homo sapiens (Human)
Expression Region
1-344
Target Protein Sequence
MAAAGARPVE LGFAESAPAW RLRSEQFPSK VGGRPAWLGA AGLPGPQALA CELCGRPLSF LLQVYAPLPG RPDAFHRCIF LFCCREQPCC AGLRVFRNQL PRKNDFYSYE PPSENPPPET GESVCLQLKS GAHLCRVCGC LGPKTCSRCH KAYYCSKEHQ TLDWRLGHKQ ACAQPDHLDH IIPDHNFLFP EFEIVIETED EIMPEVVEKE DYSEIIGSMG EALEEELDSM AKHESREDKI FQKFKTQIAL EPEQILRYGR GIAPIWISGE NIPQEKDIPD CPCGAKRILE FQVMPQLLNY LKADRLGKSI DWGILAVFTC AESCSLGTGY TEEFVWKQDV TDTP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.
Gene References into Functions
  1. PDCD2 and NCoR1 may act as tumor suppressors in Gastrointestinal stromal tumors cells through the Smad signaling pathway. PMID: 26589942
  2. PDCD2 may play an important role in tumor suppression in osteosarcoma. These mechanisms might be related to immune response induced by CD4(+) and CD8(+) T cells. PMID: 26617804
  3. Low PDCD2 expression is associated with gastric cancer. PMID: 25111461
  4. Loss of PDCD2 expression could contribute to gastric cancer development and progression. PMID: 25334010
  5. Expression of human PDCD2 fully rescues the Drosophila Zfrp8 phenotype, underlining the functional conservation of Zfrp8/PDCD2. PMID: 24381196
  6. PDCD2 RNA expression in acute leukemia patients correlates with disease status and is a significant predictor of clinical relapse. PMID: 23760497
  7. PDCD2 has a novel regulatory role in human hematopoiesis and is essential for erythroid development. PMID: 22922207
  8. Transfection of a construct expressing PDCD2 induces apoptosis in human cell lines through activation of the caspase cascade. PMID: 20605493
  9. To study the role of PDCD2_C domain in apoptosis, the cDNAs of two isoforms of PDCD2 and MGC13096 were cloned. PDCD2 (NM_002598) was over expressed when endothelial cells treated with leukotriene D4 or natural killer cells were activated by IL-2. PMID: 16311922
  10. repression of PDCD2 by BCL6 is likely important in the pathogenesis of certain human lymphomas PMID: 17468402

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Subcellular Location
Nucleus.
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 8762

OMIM: 600866

KEGG: hsa:5134

STRING: 9606.ENSP00000439467

UniGene: Hs.367900

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