PDE6D Antibody

Datasheet

Code	CSB-PA526126LA01HU
Size	US$166
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Image	Western blot All lanes: PDE6D antibody at 1.5µg/ml Lane 1: A549 whole cell lysate Lane 2: MCF-7 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 18 kDa Observed band size: 18 kDa Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA526126LA01HU at dilution of 1:100
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Product Details
Citations
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PDE6D Polyclonal antibody

Uniprot No.

O43924

Target Names

PDE6D

Alternative Names

5''-cyclic phosphodiesterase subunit delta antibody; GMP PDE delta antibody; GMP-PDE delta antibody; p17 protein antibody; PDE 6 antibody; PDE 6D antibody; PDE D antibody; PDE6 antibody; PDE6D antibody; PDE6D_HUMAN antibody; PDED antibody; Phosphodiesterase 6D cGMP specific antibody; Phosphodiesterase 6D cGMP specific rod delta antibody; Protein p17 antibody; Retinal rod photoreceptor cGMP phosphodiesterase delta antibody; Retinal rod rhodopsin sensitive cGMP 3' 5' cyclic phosphodiesterase subunit delta antibody; Retinal rod rhodopsin-sensitive cGMP 3'' antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Retinal rod rhodopsin-sensitive cGMP 3\\\',5\\\'-cyclic phosphodiesterase subunit delta protein (1-150AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PDE6D Antibody (Product code: CSB-PA526126LA01HU) is Non-conjugated. For PDE6D Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA526126LB01HU	PDE6D Antibody, HRP conjugated	ELISA
FITC	CSB-PA526126LC01HU	PDE6D Antibody, FITC conjugated
Biotin	CSB-PA526126LD01HU	PDE6D Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling T Yelland,Journal of Medicinal Chemistry,2022

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : Western blot analysis

Sample type: cell

Review: Anti-KRAS monoclonal antibody WH00034845M1 (SIGMA) and anti-PDE6D polyclonal antibody CSB-PA526126LA01HU (CUSABIO, Houston, TX, USA) were raised against the human proteins. The same antibodies were used for the murine cell line NIH-3T3, where KRAS and PDE6D showed 97.3 and 98% sequence identity with the human proteins, respectively.

By Anonymous

Target Background

Function

Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate.

Gene References into Functions

PDE6delta binds selectively to the C-terminus of RPGR and that this interaction is critical for RPGR's localization to cilia. PMID: 28172980
Studies indicate that the binding of UNC119 and PDE6D, to the lipid-modified ciliary cargo and the specific release of the cargo in the cilia by the ciliary small G-protein Arl3 in a GTP-dependent manner. PMID: 27911709
Study identifies PDE6D as a novel Joubert syndrome gene and provides the first evidence of prenyl-binding-dependent trafficking in ciliopathies. PMID: 24166846
RPGR is acting as a scaffold protein recruiting cargo-loaded PDE6D and Arl3 to release lipidated cargo into cilia. PMID: 23559067
findings indicate that ARL13B, INPP5E, PDE6D, and CEP164 form a distinct functional network that is involved in JBTS and NPHP but independent of the ones previously defined by NPHP and MKS proteins PMID: 23150559
Data show that PDEdelta activity augments K/Hras signalling by enriching Ras at the plasma membrane. PMID: 22179043

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Involvement in disease

Joubert syndrome 22 (JBTS22)

Subcellular Location

Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, cilium basal body.

Protein Families

PDE6D/unc-119 family

Tissue Specificity

Widely expressed. Detected in various tissues including spleen, prostate gland, testis, ovary, small intestine, colon, retina, and peripheral blood.

Database Links

HGNC: 8788

OMIM: 602676

KEGG: hsa:5147

STRING: 9606.ENSP00000287600

UniGene: Hs.516808

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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