PEX11B Antibody

Code CSB-PA017796LA01HU
Size US$166
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  • Western blot
    All lanes: PEX11B antibody at 10µg/ml
    Lane 1: 293T whole cell lysate
    Lane 2: Hela whole cell lysate
    Lane 3: K562 whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 29, 27 kDa
    Observed band size: 27 kDa

  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017796LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017796LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA017796LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PEX11B Polyclonal antibody
Uniprot No.
Target Names
PEX11B
Alternative Names
PEX11B; Peroxisomal membrane protein 11B; Peroxin-11B; Peroxisomal biogenesis factor 11B; Protein PEX11 homolog beta; PEX11-beta
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Peroxisomal membrane protein 11B protein (9-228AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PEX11B Antibody (Product code: CSB-PA017796LA01HU) is Non-conjugated. For PEX11B Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA017796LB01HU PEX11B Antibody, HRP conjugated ELISA
FITC CSB-PA017796LC01HU PEX11B Antibody, FITC conjugated
Biotin CSB-PA017796LD01HU PEX11B Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in peroxisomal proliferation. May regulate peroxisome division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. Promotes membrane protrusion and elongation on the peroxisomal surface.
Gene References into Functions
  1. Next generation sequencing identified biallelic loss-of-function mutations in PEX11B as the underlying cause of disease in each case (PEX11B c.235C>T p.(Arg79Ter) homozygous; PEX11B c.136C>T p.(Arg46Ter) homozygous; PEX11B c.595C>T p.(Arg199Ter) heterozygous, PEX11B ex1-3 del heterozygous). PMID: 28129423
  2. Self-interaction of human Pex11beta during peroxisomal growth and division regulates its membrane deforming activity in conjunction with membrane lipids. PMID: 23308220
  3. Excluding mutations in all PEX genes previously implicated in peroxisome biogenesis disorders, it was found that the defect was caused by a homozygous non-sense mutation in the PEX11beta gene. PMID: 22581968
  4. A new study identifies the first patient with a mutation in PEX11beta.These new findings widen the spectrum of clinical and cellular phenotypes of peroxisome biogenesis disorders. PMID: 22581969
  5. coordinates peroxisome membrane proliferation and maintenance PMID: 20826455
  6. Fis1 plays important roles in peroxisome division and maintenance of peroxisome morphology in mammalian cells, possibly in a concerted manner with Pex11pbeta and DLP1. PMID: 17408615

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Involvement in disease
Peroxisome biogenesis disorder 14B (PBD14B)
Subcellular Location
Peroxisome membrane; Single-pass membrane protein.
Protein Families
Peroxin-11 family
Database Links

HGNC: 8853

OMIM: 603867

KEGG: hsa:8799

STRING: 9606.ENSP00000358312

UniGene: Hs.714608

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