PIGO Antibody

Datasheet

Code	CSB-PA855068LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA855068LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA855068LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PIGO Polyclonal antibody

Uniprot No.

Q8TEQ8

Target Names

PIGO

Alternative Names

PIGO antibody; UNQ632/PRO1249 antibody; GPI ethanolamine phosphate transferase 3 antibody; EC 2.-.-.- antibody; Phosphatidylinositol-glycan biosynthesis class O protein antibody; PIG-O antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PIGO Antibody (Product code: CSB-PA855068LA01HU) is Non-conjugated. For PIGO Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA855068LB01HU	PIGO Antibody, HRP conjugated	ELISA
FITC	CSB-PA855068LC01HU	PIGO Antibody, FITC conjugated
Biotin	CSB-PA855068LD01HU	PIGO Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.

Gene References into Functions

PIGO deficiency shows variable phenotypes from infantile lethality to mild learning difficulties PMID: 28337824
Disease associated PIGO missense mutations resulted in decreased activity in vitro. PMID: 28327575
Novel PIGO mutations expand the clinical spectrum of PIGO abnormalities to include epileptic encephalopathy with mild elevation of alkaline phosphatase (ALP). PMID: 24417746
Our data identify PIGO as the second gene associated with HPMRS and suggest that a deficiency in GPI-anchor synthesis is the underlying molecular pathomechanism of HPMRS. PMID: 22683086

Involvement in disease

Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

PIGG/PIGN/PIGO family, PIGO subfamily

Database Links

HGNC: 23215

OMIM: 614730

KEGG: hsa:84720

STRING: 9606.ENSP00000339382

UniGene: Hs.522099

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Related pathways

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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