PIGO Antibody

Code CSB-PA855068LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA855068LA01HU at dilution of 1:100

  • Immunofluorescent analysis of A549 cells using CSB-PA855068LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PIGO Polyclonal antibody
Uniprot No.
Target Names
PIGO
Alternative Names
PIGO antibody; UNQ632/PRO1249 antibody; GPI ethanolamine phosphate transferase 3 antibody; EC 2.-.-.- antibody; Phosphatidylinositol-glycan biosynthesis class O protein antibody; PIG-O antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human GPI ethanolamine phosphate transferase 3 protein (219-420AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PIGO Antibody (Product code: CSB-PA855068LA01HU) is Non-conjugated. For PIGO Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA855068LB01HU PIGO Antibody, HRP conjugated ELISA
FITC CSB-PA855068LC01HU PIGO Antibody, FITC conjugated
Biotin CSB-PA855068LD01HU PIGO Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond.
Gene References into Functions
  1. PIGO deficiency shows variable phenotypes from infantile lethality to mild learning difficulties PMID: 28337824
  2. Disease associated PIGO missense mutations resulted in decreased activity in vitro. PMID: 28327575
  3. Novel PIGO mutations expand the clinical spectrum of PIGO abnormalities to include epileptic encephalopathy with mild elevation of alkaline phosphatase (ALP). PMID: 24417746
  4. Our data identify PIGO as the second gene associated with HPMRS and suggest that a deficiency in GPI-anchor synthesis is the underlying molecular pathomechanism of HPMRS. PMID: 22683086
Involvement in disease
Hyperphosphatasia with mental retardation syndrome 2 (HPMRS2)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
PIGG/PIGN/PIGO family, PIGO subfamily
Database Links

HGNC: 23215

OMIM: 614730

KEGG: hsa:84720

STRING: 9606.ENSP00000339382

UniGene: Hs.522099

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