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PIK3R5 Antibody

Datasheet
Code CSB-PA288007
Size US$297
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Image
  • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PIK3R5 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PIK3R5 Polyclonal antibody
Uniprot No.
Q8WYR1
Target Names
PIK3R5
Alternative Names
5-bisphosphate 3-kinase regulatory subunit antibody; F730038I15Rik antibody; FOAP 2 antibody; FOAP2 antibody; OTTHUMP00000135339 antibody; p101 antibody; P101 PI3K antibody; p101-PI3K antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody; Phosphoinositide 3 kinase, regulatory subunit 5 antibody; Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody; Phosphoinositide 3-kinase regulatory subunit 5 antibody; PI3 kinase p101 subunit antibody; PI3 kinase regulatory subunit 5 antibody; PI3-kinase p101 subunit antibody; PI3-kinase regulatory subunit 5 antibody; PI3R5_HUMAN antibody; PIK3 R5 antibody; PIK3R5 antibody; Protein FOAP 2 antibody; Protein FOAP-2 antibody; PtdIns 3 kinase p101 antibody; PtdIns 3 kinase regulatory subunit antibody; PtdIns-3-kinase p101 antibody; PtdIns-3-kinase regulatory subunit antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human PIK3R5.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB,IHC,IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
IHC 1:50-1:200
IF 1:100-1:200
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Usage
For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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PIK3R5 Antibodies

PIK3R5 Proteins

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Target Background

Function
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
Gene References into Functions
  1. data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
  2. PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
  3. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
  4. Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID: 22065524
  5. p101 has a role in membrane recruitment and activation of PI3K gamma PMID: 12507995
  6. analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID: 15611065
  7. Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID: 17486067

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Involvement in disease
Ataxia-oculomotor apraxia 3 (AOA3)
Subcellular Location
Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
Tissue Specificity
Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
Database Links

HGNC: 30035

OMIM: 611317

KEGG: hsa:23533

STRING: 9606.ENSP00000392812

UniGene: Hs.278901

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Related pathways
PI3K-Akt signaling pathway Apelin signaling pathway cGMP-PKG signaling pathway Oxidative Phosphorylation Phospholipase D signaling pathway
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