PIK3R5 Antibody

Code CSB-PA008386
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Product Details

Uniprot No. Q8WYR1
Target Names PIK3R5
Alternative Names 5-bisphosphate 3-kinase regulatory subunit antibody; F730038I15Rik antibody; FOAP 2 antibody; FOAP2 antibody; OTTHUMP00000135339 antibody; p101 antibody; P101 PI3K antibody; p101-PI3K antibody; Phosphatidylinositol 4 antibody; Phosphatidylinositol 4,5 bisphosphate 3 kinase regulatory subunit antibody; Phosphoinositide 3 kinase, regulatory subunit 5 antibody; Phosphoinositide 3 kinase, regulatory subunit 5, p101 antibody; Phosphoinositide 3 kinase, regulatory subunit, polypeptide p101 antibody; Phosphoinositide 3-kinase regulatory subunit 5 antibody; PI3 kinase p101 subunit antibody; PI3 kinase regulatory subunit 5 antibody; PI3-kinase p101 subunit antibody; PI3-kinase regulatory subunit 5 antibody; PI3R5_HUMAN antibody; PIK3 R5 antibody; PIK3R5 antibody; Protein FOAP 2 antibody; Protein FOAP-2 antibody; PtdIns 3 kinase p101 antibody; PtdIns 3 kinase regulatory subunit antibody; PtdIns-3-kinase p101 antibody; PtdIns-3-kinase regulatory subunit antibody
Raised in Rabbit
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from the C-terminal region of Human PI 3-kinase p101.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG.
Gene References into Functions
  1. data argue for differential regulatory functions of the non-catalytic subunits and a specific Gbetagamma-dependent regulation of p101 in PI3Kgamma activation. PMID: 26173259
  2. PIK3R5 promoter hypermethylation is associated with oral squamous cell carcinoma. PMID: 25374236
  3. expression and activities of PI3Kgamma are modified differently by p87 and p101 in vitro and in living cells, arguing for specific regulatory roles of the non-catalytic subunits in the differentiation of PI3Kgamma signaling pathways. PMID: 24014027
  4. Our characterization of the PIK3R5 protein and findings suggest that it may play a role in the development of the cerebellum and vermis. PMID: 22065524
  5. p101 has a role in membrane recruitment and activation of PI3K gamma PMID: 12507995
  6. analysis of functional domains in the p101 regulatory subunit of phosphoinositide 3-kinase gamma PMID: 15611065
  7. Overexpression of p101 activates PI3Kgamma signaling and is associated with T-cell lymphomas PMID: 17486067

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Involvement in disease Ataxia-oculomotor apraxia 3 (AOA3)
Subcellular Location Nucleus. Cytoplasm. Cell membrane; Peripheral membrane protein.
Tissue Specificity Ubiquitously expressed with high expression in fetal brain compared to adult brain. Abundant expression is observed in cerebellum, cerebral cortex, cerebral meninges, and vermis cerebelli.
Database Links

HGNC: 30035

OMIM: 611317

KEGG: hsa:23533

STRING: 9606.ENSP00000392812

UniGene: Hs.278901

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