PKMYT1 Antibody

Code CSB-PA16029A0Rb
Size US$166
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  • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA16029A0Rb at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16029A0Rb at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PKMYT1 Polyclonal antibody
Uniprot No.
Target Names
PKMYT1
Alternative Names
cdc2 inhibitory kinase antibody; DKFZp547K1610 antibody; FLJ20093 antibody; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase antibody; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody; MYT1 antibody; Myt1 kinase antibody; PKMYT 1 antibody; Pkmyt1 antibody; PMYT1_HUMAN antibody; PPP1R126 antibody; Protein kinase membrane associated tyrosine/threonine 1 antibody; Protein kinase Myt1 antibody; Protein phosphatase 1 regulatory subunit 126 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein (900-1101AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PKMYT1 Antibody (Product code: CSB-PA16029A0Rb) is Non-conjugated. For PKMYT1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA16029B0Rb PKMYT1 Antibody, HRP conjugated ELISA
FITC CSB-PA16029C0Rb PKMYT1 Antibody, FITC conjugated
Biotin CSB-PA16029D0Rb PKMYT1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Gene References into Functions
  1. Study found that PKMYT1 was essential for the proliferation and mobility of CRC cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease. PMID: 29658598
  2. PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells PMID: 28648520
  3. Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis. PMID: 23241949
  4. MYT1 binds to TSAP6 in tumor cells and has a role in cell cycle regulation PMID: 12606722
  5. Myt1 is phosphorylated by polo-like kinase 1 PMID: 12738781
  6. overexpressed during the S phase of the cell cycle compared with the G0/1 phase PMID: 16476973
  7. The results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells. PMID: 18378775

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Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.
Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Database Links

HGNC: 29650

OMIM: 602474

KEGG: hsa:9088

STRING: 9606.ENSP00000262300

UniGene: Hs.732385

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