PKMYT1 Antibody

Datasheet

Code	CSB-PA16029A0Rb
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA16029A0Rb at dilution of 1:100 Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA16029A0Rb at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PKMYT1 Polyclonal antibody

Uniprot No.

Q99640

Target Names

PKMYT1

Alternative Names

cdc2 inhibitory kinase antibody; DKFZp547K1610 antibody; FLJ20093 antibody; Membrane associated tyrosine and threonine specific cdc2 inhibitory kinase antibody; Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase antibody; MYT1 antibody; Myt1 kinase antibody; PKMYT 1 antibody; Pkmyt1 antibody; PMYT1_HUMAN antibody; PPP1R126 antibody; Protein kinase membrane associated tyrosine/threonine 1 antibody; Protein kinase Myt1 antibody; Protein phosphatase 1 regulatory subunit 126 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase protein (900-1101AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PKMYT1 Antibody (Product code: CSB-PA16029A0Rb) is Non-conjugated. For PKMYT1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA16029B0Rb	PKMYT1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA16029C0Rb	PKMYT1 Antibody, FITC conjugated
Biotin	CSB-PA16029D0Rb	PKMYT1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Gene References into Functions

Study found that PKMYT1 was essential for the proliferation and mobility of CRC cells in vitro. Also, results demonstrated that patients expressing high level of PKMYT1 displayed a worse overall survival rate than those with a low level of PKMYT1. These data indicated that PKMYT1 was a biomarker for the prediction of the prognosis of the disease. PMID: 29658598
PKMYT1 positively regulated the growth, migration, colony formation, metastasis and epithelia mesenchymal transition of hepatocellular carcinoma cells PMID: 28648520
Myt1 is inactivated by MEK1 mediated phosphorylation to fragment the Golgi complex in G2 and for the entry of cells into mitosis. PMID: 23241949
MYT1 binds to TSAP6 in tumor cells and has a role in cell cycle regulation PMID: 12606722
Myt1 is phosphorylated by polo-like kinase 1 PMID: 12738781
overexpressed during the S phase of the cell cycle compared with the G0/1 phase PMID: 16476973
The results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis in Hela cells. PMID: 18378775

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Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein.

Protein Families

Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily

Database Links

HGNC: 29650

OMIM: 602474

KEGG: hsa:9088

STRING: 9606.ENSP00000262300

UniGene: Hs.732385

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Cell cycle

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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